中度严重营养不良患者的辩证内部营养:多中心前瞻性观察研究

Concetto Sessa, Walter Morale, Antonino Reina, G. Battaglia, Sandra La Rosa, Daniela Puliatti, G. Seminara, Luca Zanoli
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引用次数: 0

摘要

透析患者有各种各样的病理,导致他们身体虚弱。保持良好的营养状态有助于预防和治疗所谓的蛋白质能量消耗(PEW),这是一种复杂的临床-实验室条件,发生蛋白质能量消耗。慢性肾病患者坚持适当的营养治疗需要患者和医护人员(医生和护士)付出相当大的努力。为了减缓营养不良的影响和使皮尤研究中心复杂化的灾难,肾病学家可以使用补充产品。在我们的观察性、前瞻性、多中心研究中,我们通过连接到静脉导管的输注泵给患者静脉输注一种三室乳剂的静脉外营养。治疗12周后,严重营养不良患者的比例从61.1%下降到33.3%,血清肌酐升高16%(从6.00±1.48 mg/dL上升到6.98±2.46 mg/dL;P < 0.001),总蛋白和白蛋白水平分别下降13%(从5.46±0.63 g/dL降至6.19±0.66 g/dL;P < 0.001), 19%(从2.70±0.48 g/dL降至3.20±0.57 g/dL;P < 0.001),体重下降3%(从55.7±13.2 kg降至57.6±13.0 kg;P < 0.001)。
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Nutrizione parenterale intradialitica in pazienti con malnutrizione moderata-severa: studio prospettico osservazionale multicentrico
Dialysis patients have a wide range of pathologies that contribute to their frailty. Maintaining a good nutritional status is useful to prevent and treat the so-called Protein-Energy Wasting (PEW), a complex clinical-laboratory condition in which a protein-energy depletion occurs. Adherence to a proper nutritional therapy in CKD requires considerable effort from both patients and health personnel (doctors and nurses). In order to slow down the effects of malnutrition and the disasters that complicate PEW, nephrologists can use supplementation products. In our observational, prospective, multicentre study, we administered an intradialytic parenteral nutrition of a three-compartment emulsion for intravenous infusion through an infusion pump connected to the venous line. After 12 weeks of treatment, subjects with severe malnutrition were reduced from 61.1% to 33.3%, serum creatinine increased by 16% (from 6.00 ± 1.48 mg/dL to 6.98 ± 2.46 mg/dL; P < 0.001), total protein and albumin levels respectively by 13% (from 5.46 ± 0.63 g/dL to 6.19 ± 0.66 g/dL; P < 0.001) and 19% (from 2.70 ± 0.48 g/dL to 3.20 ± 0.57 g/dL; P < 0.001), body weight by 3% (from 55.7 ± 13.2 kg to 57.6 ± 13.0 kg; P < 0.001).
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Percorsi diagnostico-terapeutici condivisi nel territorio sardo in nefrologia e dialisi. Oristano, 29-30 Novembre-1 Dicembre 2023 Abstracts 42° Congresso Nazionale SIAN ITALIA. Infermieristica nefrologica: ruolo‚ competenze e sostenibilità, Riccione 6-8 Maggio 2024 MRC avanzata e genere: una visione pluriprospettica /multidimensionale Nutritional therapy in Chronic Kidney Disease Infective complications in the renal transplant recipients
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