工艺参数对脂质体制剂关键属性的影响

Bayan Abu Ras, Youssef Haggag, M. Isreb, M. El Tanani
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引用次数: 0

摘要

本研究探讨了工艺参数对rani - rcc1抑制肽(RANIP)和阿霉素(DOX)脂质体制剂对乳腺癌共递送的大小、分布、zeta电位和负载效率的影响。结果表明,药物浓度、pH和超声强度是控制脂质体属性的关键因素。
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Effect of Process Parameters on the critical attributes of the Liposomal formulations
This study investigate the effect of processparameters on the size, distribution, zeta potential  and loading efficiency for the co-delivery of liposomalformulation of Ran-RCC1 inhibitory peptide (RANIP) and doxorubicin (DOX) tobreast cancer. The results showthat drug concentration, pH and ultrasound intensity are all critical factors tocontrol the attributes of the liposomes.
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