5-hT2A受体对离体小鼠攻击行为的调节。

M. Sakaue, Y. Ago, C. Sowa, Y. Sakamoto, Beni Nishihara, Y. Koyama, A. Baba, T. Matsuda
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引用次数: 69

摘要

本研究旨在探讨分离饲养是否会影响小鼠5-羟色胺(5-HT)2A受体的敏感性以及5-HTIA和5-HT2A受体之间的功能相互作用。5- ht2a受体激动剂(+/-)-1-(2,5-二甲氧基-4-碘苯基)-2-氨基丙烷盐酸盐(DOI)诱导的小鼠抽头反应在离体小鼠中明显大于分组小鼠。DOI增加了隔离诱导的攻击行为,而5- ht2a受体拮抗剂利坦色林则降低了这种行为。5- htia受体激动剂(S)-5-[3-[(1,4-苯二氧基-2-甲基)氨基]丙氧基]-1,3-苯二氧基HCl (MKC-242)可抑制doi增强的攻击行为。MKC-242抑制doi诱导的头抽搐反应。这些发现表明5-HT2A受体在离体小鼠的攻击行为中发挥作用,并暗示MKC-242的抗攻击作用可能部分是通过抑制5-HT2A受体功能来介导的。
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Modulation by 5-hT2A receptors of aggressive behavior in isolated mice.
The present study examines whether isolation-rearing affects sensitivity of 5-hydroxytryptamine (5-HT)2A receptors and the functional interaction between 5-HTIA and 5-HT2A receptors in mice. The 5-HT2A-receptor agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI)-induced head twitch response was significantly greater in isolated mice than in grouped mice. DOI increased isolation-induced aggressive behavior, and the 5-HT2A-receptor antagonist ritanserin decreased it. The 5-HTIA-receptor agonist (S)-5-[3-[(1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole HCl (MKC-242) inhibited the DOI-enhanced aggressive behavior. MKC-242 inhibited DOI-induced head twitch response. These findings suggest that 5-HT2A receptors play a role in aggressive behavior in isolated mice and imply that the antiaggressive effect of MKC-242 may be mediated partly by the inhibition of 5-HT2A-receptor function.
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