肺功能检查和计算机断层体积定量分析在评估特发性肺纤维化中的作用

IF 0.2 Q4 RESPIRATORY SYSTEM Egyptian Journal of Chest Diseases and Tuberculosis Pub Date : 2023-04-01 DOI:10.4103/ecdt.ecdt_71_22
Omina Zaki, R. Sharshar, R. Younes, A. Abdella
{"title":"肺功能检查和计算机断层体积定量分析在评估特发性肺纤维化中的作用","authors":"Omina Zaki, R. Sharshar, R. Younes, A. Abdella","doi":"10.4103/ecdt.ecdt_71_22","DOIUrl":null,"url":null,"abstract":"Background Idiopathic pulmonary fibrosis (IPF) is a progressive irreversible lung disease, but early assessment by pulmonary function tests (PFTs) and quantitative volumetric computed tomography (CT) analysis aid in diagnosis, disease monitoring, and prognosis in patients with IPF. Objectives The study aimed to study the role of quantitative volumetric CT indices and PFTs in assessing disease severity in patients with IPF. Patients and methods The study included 40 patients with IPF diagnosed by usual interstitial pneumonia pattern in high-resolution CT and subdivided into two groups according to the GAP staging system (sex, age, and physiology): group I included patients with IPF stage I (five patients) and stage II (15 patients), whereas group II included patients with IPF stage III (20 patients). Clinical history taking, physical examination, plain chest radiography to exclude other diagnosis, PFTs, and quantitative volumetric high-resolution CT were done for all patients. Results There was a significant difference between group I [higher normal attenuating lung volume (NL%) and lower honeycombing area volume (HA%)] versus group II (lower NL% and higher HA%), with no significant difference in whole lung volume (WL) between the two groups. There was a significant correlation between radiological parameters (NL% and HA%) and modified Medical Research Council score of dyspnea and GAP staging system. Radiological parameters (NL% and HA%) had a significant correlation with functional parameters (forced vital capacity% and diffusing capacity for carbon monoxide%). Furthermore, NL% and HA% showed a negative significant correlation with each other. Conclusions PFTs and quantitative volumetric CT parameters showed a statistically significant difference among IPF cases of various severity, and both are highly correlated with each other and with clinical modified Medical Research Council score of dyspnea score of dyspnea and GAP staging system. So, both can play a major role not only in diagnosis but also in detecting severity and predicting mortality in IPF.","PeriodicalId":46359,"journal":{"name":"Egyptian Journal of Chest Diseases and Tuberculosis","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Role of pulmonary function tests and computed tomography volumetric quantitative analysis in assessment of idiopathic pulmonary fibrosis\",\"authors\":\"Omina Zaki, R. Sharshar, R. Younes, A. Abdella\",\"doi\":\"10.4103/ecdt.ecdt_71_22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background Idiopathic pulmonary fibrosis (IPF) is a progressive irreversible lung disease, but early assessment by pulmonary function tests (PFTs) and quantitative volumetric computed tomography (CT) analysis aid in diagnosis, disease monitoring, and prognosis in patients with IPF. Objectives The study aimed to study the role of quantitative volumetric CT indices and PFTs in assessing disease severity in patients with IPF. Patients and methods The study included 40 patients with IPF diagnosed by usual interstitial pneumonia pattern in high-resolution CT and subdivided into two groups according to the GAP staging system (sex, age, and physiology): group I included patients with IPF stage I (five patients) and stage II (15 patients), whereas group II included patients with IPF stage III (20 patients). Clinical history taking, physical examination, plain chest radiography to exclude other diagnosis, PFTs, and quantitative volumetric high-resolution CT were done for all patients. Results There was a significant difference between group I [higher normal attenuating lung volume (NL%) and lower honeycombing area volume (HA%)] versus group II (lower NL% and higher HA%), with no significant difference in whole lung volume (WL) between the two groups. There was a significant correlation between radiological parameters (NL% and HA%) and modified Medical Research Council score of dyspnea and GAP staging system. Radiological parameters (NL% and HA%) had a significant correlation with functional parameters (forced vital capacity% and diffusing capacity for carbon monoxide%). Furthermore, NL% and HA% showed a negative significant correlation with each other. Conclusions PFTs and quantitative volumetric CT parameters showed a statistically significant difference among IPF cases of various severity, and both are highly correlated with each other and with clinical modified Medical Research Council score of dyspnea score of dyspnea and GAP staging system. So, both can play a major role not only in diagnosis but also in detecting severity and predicting mortality in IPF.\",\"PeriodicalId\":46359,\"journal\":{\"name\":\"Egyptian Journal of Chest Diseases and Tuberculosis\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2023-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Egyptian Journal of Chest Diseases and Tuberculosis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ecdt.ecdt_71_22\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"RESPIRATORY SYSTEM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Egyptian Journal of Chest Diseases and Tuberculosis","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ecdt.ecdt_71_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RESPIRATORY SYSTEM","Score":null,"Total":0}
引用次数: 0

摘要

特发性肺纤维化(IPF)是一种进行性不可逆的肺部疾病,但通过肺功能试验(PFTs)和定量容积计算机断层扫描(CT)分析进行早期评估有助于IPF患者的诊断、疾病监测和预后。目的探讨定量CT容积指数和pft在IPF患者疾病严重程度评估中的作用。患者和方法本研究纳入40例高分辨率CT诊断为常规间质性肺炎的IPF患者,并根据GAP分期系统(性别、年龄和生理)细分为两组:I组包括IPF I期(5例)和II期(15例)患者,II组包括IPF III期(20例)患者。所有患者均进行了临床病史、体格检查、排除其他诊断的胸部平片、pft和定量高分辨率体积CT检查。结果ⅰ组[正常衰减肺体积(NL%)升高、蜂窝状面积体积(HA%)降低]与ⅱ组(NL%降低、HA%升高)差异有统计学意义,两组间全肺体积(WL)无统计学差异。放射学参数(NL%和HA%)与改进的医学研究委员会呼吸困难评分和GAP分期系统有显著相关性。放射学参数(NL%和HA%)与功能参数(强迫肺活量%和一氧化碳扩散量%)有显著相关性。NL%与HA%呈显著负相关。结论不同严重程度IPF患者pft与定量容积CT参数差异均有统计学意义,且两者之间及与临床改良医学研究委员会呼吸困难评分及GAP分期系统高度相关。因此,两者不仅可以在诊断中发挥重要作用,而且可以在检测IPF的严重程度和预测死亡率方面发挥重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Role of pulmonary function tests and computed tomography volumetric quantitative analysis in assessment of idiopathic pulmonary fibrosis
Background Idiopathic pulmonary fibrosis (IPF) is a progressive irreversible lung disease, but early assessment by pulmonary function tests (PFTs) and quantitative volumetric computed tomography (CT) analysis aid in diagnosis, disease monitoring, and prognosis in patients with IPF. Objectives The study aimed to study the role of quantitative volumetric CT indices and PFTs in assessing disease severity in patients with IPF. Patients and methods The study included 40 patients with IPF diagnosed by usual interstitial pneumonia pattern in high-resolution CT and subdivided into two groups according to the GAP staging system (sex, age, and physiology): group I included patients with IPF stage I (five patients) and stage II (15 patients), whereas group II included patients with IPF stage III (20 patients). Clinical history taking, physical examination, plain chest radiography to exclude other diagnosis, PFTs, and quantitative volumetric high-resolution CT were done for all patients. Results There was a significant difference between group I [higher normal attenuating lung volume (NL%) and lower honeycombing area volume (HA%)] versus group II (lower NL% and higher HA%), with no significant difference in whole lung volume (WL) between the two groups. There was a significant correlation between radiological parameters (NL% and HA%) and modified Medical Research Council score of dyspnea and GAP staging system. Radiological parameters (NL% and HA%) had a significant correlation with functional parameters (forced vital capacity% and diffusing capacity for carbon monoxide%). Furthermore, NL% and HA% showed a negative significant correlation with each other. Conclusions PFTs and quantitative volumetric CT parameters showed a statistically significant difference among IPF cases of various severity, and both are highly correlated with each other and with clinical modified Medical Research Council score of dyspnea score of dyspnea and GAP staging system. So, both can play a major role not only in diagnosis but also in detecting severity and predicting mortality in IPF.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
46
审稿时长
22 weeks
期刊介绍: The journal will cover technical and clinical studies related to health, ethical and social issues in field of The Egyptian Journal of Chest Diseases and Tuberculosis aims to publish and inform readers and all chest physicians of the progress in medical research concerning all aspect of chest diseases. Publications include original articles review articles, editorials, case studies and reports which are relevant to chest diseases. The Journal also aims to highlight recent updates in chest medicine. . Articles with clinical interest and implications will be given preference.
期刊最新文献
Escalation to invasive mechanical ventilation in noninvasive ventilation failure: some insights about methodology Effect of physiotherapy and its frequency on the outcome of COVID-19 patients regarding acute care setting at isolation unit of Ain Shams University Role of interleukin-6 in coronavirus disease 2019 pneumonia: sensitive marker of inflammation, a predictor of ventilatory support and early marker of post-coronavirus disease lung fibrosis. A single center experience Diagnostic performance of transthoracic ultrasound in patients with pulmonary embolism Proportion and prognosis of ICU-admitted coronavirus disease 2019-infected patients in relation to all hospitalized cases in Abbasia Chest Hospital, Cairo
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1