利用益生菌治疗和预防乳腺癌的治疗潜力

Tiago Soares, B. M. Silva, D. S. Araújo, Maria Clara Feijó de Figueiredo, Francisco Das Chagas Leal Bezerra, Eliakim Aureliano da Silva, Ana Cibele Pereira Sousa, Stella Regina Arcanjo Medeiros, C. O. Barbosa, Joilane Alves Pereira-Freire
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引用次数: 0

摘要

前言:益生菌是一种活的微生物,如果使用适量,可以提供多种益处,如预防感染,缓解过敏症状和乳糖不耐症,控制血清胆固醇,血压和妊娠糖尿病,减少胃肠道疾病,产生有益的化合物,如维生素,短链脂肪酸,并且这些微生物有证据表明对某些类型的癌症有作用。本研究旨在评估文献中关于益生菌对乳腺癌的作用的证据。方法:通过PICO策略对文献进行综合综述,并以“益生菌摄入是否对氧化应激起作用并降低乳腺癌风险”为指导问题。在MEDLINE、SciELO和PubMed上选择文章,包括2016年至2021年间发表的文章,使用关键词:“乳腺癌”、“益生菌”和“微生物群”及其组合,以葡萄牙语和英语进行,并遵循先前建立的纳入标准。结果和讨论:样本由10篇文章组成,找到的答案是:体内和体外的科学研究,有一些益生菌菌株的变化,这些研究都显示出对癌细胞的作用和/或影响,或者通过代谢途径减缓肿瘤的发展。结论:在治疗和预防乳腺癌方面显示出可能的潜力,这被认为是科学界的一项创新,因为科学界仍在与与人类健康有关的各种问题,特别是某些类型的不良预后和治疗干预困难的癌症作斗争。
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Therapeutic potential of using probiotics in the treatment and prevention of breast câncer
Introduction: Probiotics are living microorganisms that when administered in appropriate amounts, provide several benefits such as prevention of infections, relief of allergic symptoms and lactose intolerance, control of serum cholesterol, blood pressure and gestational diabetes, reduction of gastrointestinal disorders, production of beneficial compounds such as vitamins, short chain fatty acids, and such microorganisms show evidence of actions against certain types of cancers. This study aimed to evaluate the evidence available in the literature on probiotics on breast cancer. Methods: It is an integrative review of the literature, through the PICO strategy, with the guiding question “Does probiotics consumption act on oxidative stress and reduces the risk of breast cancer”? The selection of articles was made on MEDLINE, SciELO and PubMed, including those published between 2016 and 2021, using the keywords: “breast cancer” AND “probiotics” AND “microbiota” their combinations in Portuguese and English, with with previously established inclusion criteria. Results and Discussion: The sample consisted of ten articles, and the answers found were: scientific research in vivo and in vitro, with some variations of probiotics strains, where all demonstrate actions and/or effects on cancer cells or acted on metabolic pathways mitigating the development of tumors. Conclusions: The manifested potential for a possible insertion in the treatment and prevention of breast cancer, being considered an innovation for the scientific community that still fights against various types of problems related to human health, especially some types of cancers, of negative prognoses and with difficult therapeutic interventions.
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