在致死性过敏性休克的啮齿动物模型中，血小板活化因子受体拮抗剂治疗可改善血流动力学并降低肾上腺素需求

Clinical & Experimental Allergy Pub Date : 2019-11-22 DOI:10.1111/cea.13540

C. Tacquard, W. Oulehri, O. Collange, L. H. Garvey, S. Nicoll, N. Tuzin, B. Gény, P. Mertes

{"title":"在致死性过敏性休克的啮齿动物模型中，血小板活化因子受体拮抗剂治疗可改善血流动力学并降低肾上腺素需求","authors":"C. Tacquard, W. Oulehri, O. Collange, L. H. Garvey, S. Nicoll, N. Tuzin, B. Gény, P. Mertes","doi":"10.1111/cea.13540","DOIUrl":null,"url":null,"abstract":"In some cases, anaphylactic shock (AS) is still lethal, despite rapid use of epinephrine. High doses of epinephrine are associated with severe complications. Platelet‐activating factor (PAF) is secreted in massive amounts during AS, and a high plasma level is correlated with increased AS severity.","PeriodicalId":10148,"journal":{"name":"Clinical & Experimental Allergy","volume":"33 1","pages":"383 - 390"},"PeriodicalIF":0.0000,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"13","resultStr":"{\"title\":\"Treatment with a platelet‐activating factor receptor antagonist improves hemodynamics and reduces epinephrine requirements, in a lethal rodent model of anaphylactic shock\",\"authors\":\"C. Tacquard, W. Oulehri, O. Collange, L. H. Garvey, S. Nicoll, N. Tuzin, B. Gény, P. Mertes\",\"doi\":\"10.1111/cea.13540\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In some cases, anaphylactic shock (AS) is still lethal, despite rapid use of epinephrine. High doses of epinephrine are associated with severe complications. Platelet‐activating factor (PAF) is secreted in massive amounts during AS, and a high plasma level is correlated with increased AS severity.\",\"PeriodicalId\":10148,\"journal\":{\"name\":\"Clinical & Experimental Allergy\",\"volume\":\"33 1\",\"pages\":\"383 - 390\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical & Experimental Allergy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1111/cea.13540\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical & Experimental Allergy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/cea.13540","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 13

摘要

在某些情况下，过敏性休克(AS)仍然是致命的，尽管迅速使用肾上腺素。高剂量的肾上腺素与严重的并发症有关。血小板活化因子(PAF)在AS期间大量分泌，高血浆水平与AS严重程度增加相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Treatment with a platelet‐activating factor receptor antagonist improves hemodynamics and reduces epinephrine requirements, in a lethal rodent model of anaphylactic shock

In some cases, anaphylactic shock (AS) is still lethal, despite rapid use of epinephrine. High doses of epinephrine are associated with severe complications. Platelet‐activating factor (PAF) is secreted in massive amounts during AS, and a high plasma level is correlated with increased AS severity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Clinical & Experimental Allergy

自引率

0.00%

发文量