{"title":"dtpa -双酰胺衍生物中性Gd(III)， Mn(II)配合物的合成与评价","authors":"Zhen-Chuan Liao, Chao-rui Li, Zheng-yin Yang","doi":"10.1080/15533174.2014.988820","DOIUrl":null,"url":null,"abstract":"A strong chelating ligand was synthesized through the modification of DTPA by bioactive 5-fluorouracil derivatives and characterized by means of mass spectra, Fourier transform infrared spectra, elemental analysis, and nuclear magnetic resonance spectroscopy. Its complexes of Gd(III) and Mn(II) were designed as potential MRI contrast agents. Thermodynamic stability constant of the complexes indicated that they were stable enough to prevent the metal ions from releasing. Relaxivity studies showed that the two complexes provided higher T1-weighted relaxivity than that of commercial contrast agent Gd-DTPA and the Mn(II) complex owned much higher T2-weighted relaxation property. Both the Gd(III) and Mn(II) complexes had the advantage of becoming promising T1-weighted MRI contrast agents.","PeriodicalId":22118,"journal":{"name":"Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2016-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Synthesis and Evaluation of Neutral Gd(III), Mn(II) Complexes From DTPA-Bisamide Derivative as Potential MRI Contrast Agents\",\"authors\":\"Zhen-Chuan Liao, Chao-rui Li, Zheng-yin Yang\",\"doi\":\"10.1080/15533174.2014.988820\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A strong chelating ligand was synthesized through the modification of DTPA by bioactive 5-fluorouracil derivatives and characterized by means of mass spectra, Fourier transform infrared spectra, elemental analysis, and nuclear magnetic resonance spectroscopy. Its complexes of Gd(III) and Mn(II) were designed as potential MRI contrast agents. Thermodynamic stability constant of the complexes indicated that they were stable enough to prevent the metal ions from releasing. Relaxivity studies showed that the two complexes provided higher T1-weighted relaxivity than that of commercial contrast agent Gd-DTPA and the Mn(II) complex owned much higher T2-weighted relaxation property. Both the Gd(III) and Mn(II) complexes had the advantage of becoming promising T1-weighted MRI contrast agents.\",\"PeriodicalId\":22118,\"journal\":{\"name\":\"Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-05-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/15533174.2014.988820\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/15533174.2014.988820","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis and Evaluation of Neutral Gd(III), Mn(II) Complexes From DTPA-Bisamide Derivative as Potential MRI Contrast Agents
A strong chelating ligand was synthesized through the modification of DTPA by bioactive 5-fluorouracil derivatives and characterized by means of mass spectra, Fourier transform infrared spectra, elemental analysis, and nuclear magnetic resonance spectroscopy. Its complexes of Gd(III) and Mn(II) were designed as potential MRI contrast agents. Thermodynamic stability constant of the complexes indicated that they were stable enough to prevent the metal ions from releasing. Relaxivity studies showed that the two complexes provided higher T1-weighted relaxivity than that of commercial contrast agent Gd-DTPA and the Mn(II) complex owned much higher T2-weighted relaxation property. Both the Gd(III) and Mn(II) complexes had the advantage of becoming promising T1-weighted MRI contrast agents.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
