用溴化铋(III)共轭加成吲哚与α，β-不饱和酮

Green and Sustainable Chemistry Pub Date : 2019-07-18 DOI:10.4236/GSC.2019.93005

Tyler J. Rauwolf, Zhi Geng, Zachary P. Kinney, Jared Renfroe, Jack Roireau, Lauren Yep, R. Mohan

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引用次数: 2

摘要

报道了一种在乙醇(190度)中使用BiBr3偶联吲哚到多种查尔酮的有效方法。产品通过一个简单的程序分离，避免了水的工作和广泛的色谱，从而最大限度地减少浪费。从绿色化学的角度来看，铋(III)化合物尤其具有吸引力，因为它们具有显著的无毒、无腐蚀性和相对便宜的特点。

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Conjugate Addition of Indoles to α,β-Unsaturated Ketones Using Bismuth (III) Bromide

An efficient method for the conjugate addition of indoles to a variety of chalcones using BiBr3 in ethanol (190 proof) is reported. Products are isolated by a simple procedure that avoids an aqueous work up and extensive chromatography, thus minimizing waste. Bismuth (III) compounds are especially attractive from a green chemistry perspective because they are remarkably nontoxic, non-corrosive and relatively inexpensive.

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Green and Sustainable Chemistry

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