三乙酸乙酯对PHBHHx的机械强度和自由表面能的评价:防止腹腔粘连

IF 2.1 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of Bioactive and Compatible Polymers Pub Date : 2023-03-13 DOI:10.1177/08839115221149726
Meryem Akkurt Yıldırım, M. Demirbilek, K. Kızılbey, Engin Kaplan, N. Türkoğlu
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引用次数: 1

摘要

几种聚合物被用于制备生物材料,如组织工程应用中的膜和薄膜。最常用的增塑剂是聚乙二醇,以获得聚合物基生物材料。另一方面,三乙酸乙酯是一种无毒的,经fda批准的增塑剂,主要用于食品工业。在本研究中,我们使用三乙酸酯作为增塑剂来获得疏水膜,以防止腹内粘连。我们选择了一种名为PHBHHx的知名聚合物,这是一种细菌聚酯,通常用作再生组织应用中细胞附着的支撑材料。我们评估了三乙酸乙酯作为增塑剂及其对机械、热、表面积、孔径和表面能的影响。生物材料表面的疏水/亲水性对比决定了生物反应。表面疏水性对细胞反应至关重要。PHBHHx的接触角测试表明,三乙酸乙酯共混后,膜的亲水性降低。用三乙酸乙酯对PHBHHx膜进行改性后,细胞粘附能力显著降低。PHBHHx膜的细胞附着率第1天为95±5%,第3天为34.5±0.9%,第5天为23±1.5%。PHBHHx/triacetin膜的细胞附着率第1天为79±2.5%,第3天为33±2.7%,第5天为13±2.1%。此外,三乙酸乙酯的掺入使比表面积从38.790 m2/g降低到32.379 m2/g。PHBHHx的断裂伸长率为128%,PHBHHx/triacetin的断裂伸长率为171%。图形抽象
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Evaluation of triacetin on mechanical strength and free surface energy of PHBHHx: The prevention of intra-abdominal adhesion
Several polymers are used for the preparation of biomaterials as membranes and films for tissue engineering applications. The most common plasticizer is PEG to obtain polymer-based biomaterials. On the other hand, triacetin is a non-toxic, FDA-approved plasticizer mostly used in the food industry. In this study, we used triacetin as a plasticizer to obtain hydrophobic membranes for the prevention of intra-abdominal adhesion. We selected a well-known polymer named PHBHHx which is a bacterial polyester generally used as supporting material for cell attachments in regenerative tissue applications. We evaluated the triacetin as a plasticizer and its effect on mechanical, thermal, surface area, pore size, and surface energy. The hydrophobic/hydrophilic contrast of a biomaterial surface determines the biological response. Surface hydrophobicity is critical for the cellular response. The contact angle tests of PHBHHx revealed that the hydrophilicity of the membrane was decreased following triacetin blending. Modification of the PHBHHx membrane by blending with triacetin caused a significant decrease in cell adhesion. The cell attachment rates of PHBHHx membranes were as 95 ± 5% on the first day, 34.5 ± 0.9% on third day, and 23 ± 1.5% on the fifth day, respectively. The rates of cell attachments on PHBHHx/triacetin membranes were determined as 79 ± 2.5% for the first day, 33 ± 2.7% for the third day, and 13 ± 2.1% for the fifth day, respectively. Besides, triacetin blending decreased the surface area from 38.790 to 32.379 m2/g. The elongation at breaks was observed as 128% for PHBHHx and 171% for PHBHHx/triacetin. Graphical abstract
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来源期刊
Journal of Bioactive and Compatible Polymers
Journal of Bioactive and Compatible Polymers 工程技术-材料科学:生物材料
CiteScore
3.50
自引率
0.00%
发文量
27
审稿时长
2 months
期刊介绍: The use and importance of biomedical polymers, especially in pharmacology, is growing rapidly. The Journal of Bioactive and Compatible Polymers is a fully peer-reviewed scholarly journal that provides biomedical polymer scientists and researchers with new information on important advances in this field. Examples of specific areas of interest to the journal include: polymeric drugs and drug design; polymeric functionalization and structures related to biological activity or compatibility; natural polymer modification to achieve specific biological activity or compatibility; enzyme modelling by polymers; membranes for biological use; liposome stabilization and cell modeling. This journal is a member of the Committee on Publication Ethics (COPE).
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