Trends of vaccination against COVID-19 among pregnant women in Siberia

Aim. To evaluate the trends of vaccination against COVID-19 among pregnant women in Siberia for the period from October 29, 2021 to November 26, 2021.Materials and Methods. The vaccination data have been collected from official records from October 29, 2021 (86,859 pregnant women) and November 26, 2021 (85,600 pregnant women) in 10 regions of Siberia.Results. Before the pregnancy onset, as of October 29, 2021, only 4,056 (4.7%) women had past medical history of COVID-19. These numbers have significantly increased to November 26, 2021 (5,656, 6.6%, p < 0.001). The number of vaccinated pregnant women increased from 4,185 (4.8%) to 8,318 (9.7%) (p < 0.001). As of November 26, 2021, we registered a reduced proportion of women vaccinated at the preconception stage (from 4.6% to 4.0%, p < 0.001), yet the number of vaccinated pregnant women raised both before (from 0.7% to 1.3 %, p < 0.001) and after 22 weeks of pregnancy (from 1.6% to 2.3%, p < 0.001). The highest proportion of pregnant women was documented in the Tyva Republic and the Irkutsk Region (p < 0.01). Major vaccination-associated adverse events have not been reported.Conclusions. The proportion of pregnant women recovered or vaccinated from COVID-19 increased from October 29, 2021 (16.4%) to November 26, 2021 (23.9%); however, this rate is clearly insufficient to reach herd immunity and reduce maternal mortality from COVID-19.