小鼠内肛门括约肌平滑肌细胞中的节律性钙瞬变

Neurogastroenterology & Motility Pub Date : 2020-03-01 DOI:10.1111/nmo.13746

Caroline A Cobine, Karen I. Hannigan, Megan McMahon, Emer Ni Bhraonain, S. Baker, K. Keef

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引用次数: 5

摘要

内肛门括约肌(IAS)表现出依赖于L型Ca2+通道(CavL)的慢波(SWs)和张力，这表明相位事件(即SWs)在张力产生中起着基本作用。本研究通过测量IAS平滑肌细胞(SMCs)中Ca2+瞬态(CTs)的时空特性，进一步研究了IAS的相活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Rhythmic calcium transients in smooth muscle cells of the mouse internal anal sphincter

The internal anal sphincter (IAS) exhibits slow waves (SWs) and tone that are dependent upon L‐type Ca2+ channels (CavL) suggesting that phasic events (ie, SWs) play a fundamental role in tone generation. The present study further examined phasic activity in the IAS by measuring the spatiotemporal properties of Ca2+ transients (CTs) in IAS smooth muscle cells (SMCs).

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Neurogastroenterology & Motility

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