用于肝癌射频消融的偶极子型应用器

Basari Basari, Aditya Rakhmadi, K. Saito
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摘要

癌症是世界上第三大死亡原因,也是最难发现和治愈的疾病之一。这一事实促使我们研究一种使用射频消融的治疗方法。射频疗法通过电磁加热杀死癌细胞。该疗法使用一个插入体内的涂抹器来加热细胞。癌细胞在短时间内(几秒到几分钟)暴露在60°C以上的温度下,从而导致细胞局部破坏。为了确保有效的治疗,我们选择了一种微创的方法,这样就可以在癌细胞内部获得良好的局部温度分布。本文提出了一种用于肝细胞间质照射技术的同轴馈电偶极子式照射器。在CST Microwave Studio中进行了涂敷器的仿真设计,在2.45 GHz的工作频率下获得了合适的尺寸。我们还考虑通过设计涂敷器的尖端来定位烧蚀区域,使电磁辐射局部存在于其周围。所提出的应用程序被插入到一个简单的具有正常和癌变肝细胞的成人人体模型中。仿真和实测结果均表明,该装置能够在2.45 GHz的中心频率下工作于血滴型消融区。通过模拟可以使癌细胞周围的温度达到60°C。此外,分析了方形四阵列涂抹器对更大肿瘤细胞的消融范围。仿真结果表明,可以获得较宽的局部烧蚀面积。
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Coax-Fed Dipole-Type Applicator for Hepatic Cancer RF Ablation
Cancer is the third leading cause of mortality in t he world and is one of the most difficult diseases to detect and cure. This fact motivates us to investigate a treatment m e hod by using radiofrequency (RF) ablation. RF abl ation therapy kills cancer cells by electromagnetically heating t hem up. The treatment uses an applicator that is in serted into the body to heat the cells. The cancer cells are exposed to a temperature of more than 60 °C in short duration (a few seconds to a few minutes), thereby causing cell destruction loca lly. To ensure effective treatment, a minimally inv asive method is selected so that good local temperature distributio n inside the cancer cells can be achieved. In this paper, a coax-fed dipole-type applicator is proposed for interstitial irradiation technique in hepatic cell treatment. The applicator design is conducted by simulation in CST Microwave Studio to obtain an appropriate size at operating frequency o f 2.45 GHz. We also consider localizing the ablation area by de signing the tip of the applicator such that the mai n electromagnetic radiation locally exists around it. The proposed ap plicator is inserted into a simple phantom model of an adult human body with normal and cancerous liver cells. Both si mulation and measured results show that the propose d applicator is able to operate at center frequency of 2.45 GHz in a blood droplet-type ablation zone. A temperature o f 60 °C around the cancer cell can be achieved by simulation. More over, a square four-array applicator is analyzed to increase the ablation zone for a larger tumor cell. The simulation results show that a reasonably wider local ablation area can be achieved.
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