分析欧洲国家COVID-19流行情况及其与非药物干预措施的关系

J. Tallon, Paulo Gomes, L. Bacelar-Nicolau
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引用次数: 6

摘要

必须通过确定受影响最严重的国家,在广泛的地理范围内了解COVID-19大流行的规模,因为要知道全世界正在遭受几种健康影响方面的不寻常中断,以及严重的经济、金融和社会影响。数据科学在了解现状和深化对2019冠状病毒病的前瞻性分析方面发挥着关键作用。本研究的主要目的是使用五个流行病学变量描述COVID-19在欧盟和其他五个经合组织国家的流行情况。其次,分析了它们与一些国家为控制和减轻流行病演变而采取的非药物措施的关系。方法对26个欧盟国家以及瑞士、挪威、土耳其、以色列和英国进行COVID-19研究。2020年5月初,以10万名居民为对象,分析了5个流行病学变量:病例总数、死亡总数、活跃病例总数、危重病例总数和检测总数。此外,还选择了8种非药物措施进行关联。采用多元统计探索性方法,包括主成分、分层和非分层(k-means)聚类分析。结果5月初,在欧盟国家和5个经合组织国家中确定了4个国家的COVID-19流行类型。在这两个集群中,共有10个国家的大流行似乎发展得更为严重,但在检测次数方面观察到不同的模式。另外两组,分别有12个和9个国家,显示出中等或低流行率,但检测模式有所不同。对于受影响更严重的两个群集的欧盟国家,研究了COVID-19遏制战略,考虑了八项非药物措施的三种实施时间模式。这三种不同的行为反映了群集的发现。以前属于第一类的国家再次出现在一起,属于第二类的国家也是如此。尽管某些措施具有共同的行为,但第2类国家通常较晚实施了其他干预措施。瑞典是一个“特例”,它只采取了其中的几项措施,而且大多数都比其他国家晚。
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Profiling European countries on COVID–19 prevalence and association with non–pharmaceutical interventions
Introduction It is essential to understand, on a large geographical scale, the dimension of the COVID–19 pandemic by identifying the most affected countries, knowing that all the world is suffering an unusual disruption regarding several health impacts, but also heavy economic, financial and social effects. A key role is reserved to Data Science to understand the present and to deepen a prospective analysis at COVID–19 day after. Objective The main objective of the present study is to describe the COVID–19 prevalence in EU and five other OECD countries using five epidemiological variables. Secondly their association with non–pharmaceutical measures taken in some countries to control and attenuate the evolution of the epidemic was analyzed. Methods The COVID–19 study covers twenty–six EU countries and additionally Switzerland, Norway, Turkey, Israel and United Kingdom. Five epidemiologic variables were analyzed by 100.000 inhabitants at the beginning of May 2020: total number of cases, total number of deaths, total number of active cases, total number of critical or serious cases and total number of tests. Also, eight non–pharmaceutical measures were selected for association purposes. A multivariate statistical exploratory approach with principal components, hierarchical and non–hierarchical (k–means) cluster analyses was applied. Results A COVID–19 prevalence typology of four country clusters was identified regarding EU countries and five OECD countries on early May. In the two clusters, with a total of ten countries where the pandemic seemed to evolve more seriously, different patterns regarding the number of tests are observed. Two other clusters, with 12 and 9 countries, show an intermediate or low prevalence but differences in testing patterns. For EU countries of both clusters more affected, COVID–19 containment strategies were studied considering three modalities of implementation timing for eight non–pharmaceutical measures. The three different behaviors mirrored the clusters findings. Countries previously classified into cluster 1 appear together again, as do countries belonging to cluster 2. In spite of a common behavior for some measures, generally countries of cluster 2 implemented other interventions later in time. Sweden is a “special case”, taking just a few of these measures, most of them later than other countries.
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