甲状腺功能测试的生化变化谱,在萨希瓦尔医学院进行

M. Rafiq, Amna Arooj, A. Siddiqa, N. Khan, S. Khan, Rabia Saeed
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摘要

背景:甲状腺疾病是世界范围内内分泌问题的主要原因之一。甲状腺功能减退症很常见,通常在女性中更为普遍。甲状腺功能检查在甲状腺疾病的诊断和监测中起着至关重要的作用。方法:经机构审查委员会批准,本横断面研究在Sahiwal医学院进行。纳入2018年8月至2020年12月病理实验室检测TFTs标本2281例。样品在Access 2型贝克曼库尔特分析仪上采用免疫化学发光法进行分析。数据分析使用社会科学统计软件包(SPSS)版本25。采用卡方检验。p值<0.05被认为是显著的。结果:共纳入2281例患者资料。参与者的平均年龄为38.86±15.30岁,以女性为主。64.1%的结果在正常范围内(甲状腺正常),其余35.9%的结果为甲状腺异常。甲亢是最常见的异常(9.5%),其次是亚临床甲状腺功能减退(8.9%)。卡方检验显示各年龄组间差异有统计学意义,p值为0.004。结论:甲状腺疾病较为常见。在我们的社区中,甲状腺功能亢进比甲状腺功能减退更普遍。关键词:甲状腺功能减退,甲亢,甲状腺疾病,亚临床甲状腺疾病
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The Spectrum of Biochemical Changes in Thyroid Function Tests, Performed at Sahiwal Medical College, Sahiwal
Background: Thyroid disorders are among one the leading causes of endocrine problems worldwide. Hypothyroidism is very common and usually is more prevalent in females. Thyroid function tests (TFTs) play a vital role in the diagnosis and monitoring of thyroid diseases. Methodology: This cross-sectional study was conducted at Sahiwal Medical College, Sahiwal after approval from the Institutional review board. The results of 2281 specimens tested for TFTs in the Pathology laboratory between August 2018 to December 2020 were included. Samples were analyzed by immunochemiluminescent assay method on an Access 2 analyzer by Beckman Coulter. Data were analyzed using Statistical Package for the Social Sciences (SPSS) version 25. A chi-square test was applied. P-value <0.05 was considered significant. Results: A total of 2281 patient data was included in the study. The mean age of participants was 38.86±15.30 years and the majority were females. 64.1% of results were within the normal limit (euthyroid) while the remaining 35.9% had abnormal thyroid profiles. Hyperthyroidism was the most common abnormality (9.5%) followed by subclinical hypothyroidism (8.9%). Chi-square test revealed a statistically significant difference in age groups, with p-value of 0.004. Conclusion: Thyroid diseases are quite common. Hyperthyroidism is slightly more prevalent than hypothyroidism in our community.  Key words: Hypothyroidism, Hyperthyroidism, Thyroid disorders, Subclinical thyroid disease.
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