成纤维细胞生长因子21:来自人类研究的新见解

J. Hansen, P. Plomgaard
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引用次数: 6

摘要

成纤维细胞生长因子21 (FGF21)是一种新的代谢调节剂,有望成为治疗2型糖尿病和肥胖的治疗靶点。然而,对FGF21的监管才刚刚出现。大多数现有的证据来自动物研究——尤其是老鼠——在动物研究中反复测量激素是很困难的。在过去的十年中,文献中出现了几项评估FGF21在人体生理学中的调节作用的研究。这些研究表明血浆FGF21是一种急性调节激素,胰高血糖素与胰岛素的比例似乎在FGF21的调节中起关键作用。在本综述中,我们评估了FGF21在人类中的调节作用,重点关注了胰高血糖素与胰岛素比率的调节作用。
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Fibroblast growth factor 21: new insights from human studies
Fibroblast growth factor 21 (FGF21) is a novel metabolic regulator that holds promise as a therapeutic target in the treatment of type 2 diabetes and obesity. The regulation of FGF21, however, is only emerging. Most of the existing evidence is derived from animal studies – particularly mice – where repeated measurements of hormones are difficult. Over the last decade, several studies evaluating the regulation of FGF21 in human physiology have emerged in the literature. These have shown that plasma FGF21 is an acutely regulated hormone and that the glucagon-to-insulin ratio seems to be pivotal in the regulation of FGF21. In the present narrative review, we evaluate the regulation of FGF21 in humans with a focus on the regulatory role of the glucagon-to-insulin ratio.
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