植物乳胶在纳米载体合成中的应用及其在药物传递中的应用

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引用次数: 0

摘要

纳米医学最重要的应用之一是利用纳米粒子进行靶向药物递送。利用基于乳胶的纳米载体作为给药系统是更好的选择,因为它既环保又无毒。本研究的主要目的是提取乳胶成分,合成纳米载体,并将其包封在特定的药物中,用于靶向给药。乳胶采集自乳胶分泌树,用极性和非极性溶剂提取。纳米载体的合成是通过微乳液技术和表面活性剂进行的。采用紫外可见光谱(UV-Vis)、红外光谱(FTIR)、气相色谱-质谱(GC-MS)和扫描电镜(SEM)对提取物及其纳米载体进行了表征。然后用药物包裹纳米载体,并检查药物释放谱。采用琼脂孔扩散法测定乳胶提取物及其纳米载体的抑菌活性,采用DPPH和TLC法测定其抗氧化活性。乳胶提取物具有抗氧化性能,载药纳米载体具有抗菌活性。
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Use of Plant Latex for Nanocarrier Synthesis and Utilizing it in Drug Delivery
One of the most significant applications of nanomedicine is employing nanoparticles for targeted drug delivery. Using latex-based nanocarrier as a drug delivery system serves as better alternatives since it is eco-friendly and rendered non-toxic. The main aim of this study is to extract latex components, synthesize nanocarriers, and encapsulate with a specific drug for its usage in targeted drug delivery. The latex was collected from a latex secreting tree and extracted using polar and non-polar solvents. The synthesis of nanocarriers was done through a microemulsion technique with the use of surfactants. The extracts and nanocarriers were characterized using UV-Vis, FTIR and GC-MS and SEM analysis. The nanocarriers were then encapsulated with a drug, and the drug release profiles are examined. Antibacterial activity of the latex extracts and loaded nanocarriers was measured by agar well diffusion technique, and antioxidant activity was determined by DPPH and TLC analysis. The latex extracts had antioxidant properties, and the drug-loaded nanocarriers had antibacterial activity.
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