国际农畜基因组学运动(CALG)

Yang Huanming
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引用次数: 0

摘要

对农业和牲畜基因组进行测序的国际协调努力已经到了时机。虽然人类基因组和与人类健康和许多模式生物的基本生物学利益有关的许多其他基因组已经测序或正在测序管道中进行,但具有重要生物学意义的作物和牲畜基因组尚未得到足够高的重视。尽管我们在政策制定、拨款资助、区域任务重点、研究界共识和技术创新等方面面临许多挑战,但基于成本效益高的大规模测序程序,即全基因组霰弹枪(WGS)测序,正在宣布和制定许多倡议。95%到99%。从这样的草图基因组中鉴定出的基因,再加上其他资源,如分子标记、大插入克隆和cDNA序列,为我们在基因组时代加速到来的农业和环境生物学方面提供了充足的信息和工具。如果这项运动取得成功,来自所有国家的分子生物学家、遗传学家和野外生物学家,无论贫富,都将被带到同一个起点,并期待基础基因组信息的另一个天文数字增长,准备好有效地将信息转化为知识,最终将改变我们的生活和环境,使其成为一个更美好的未来。我们呼吁国家和国际政府机构和组织以及研究基金会给予关注,支持这一前所未有的运动。
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An International Campaign For Agricultural and Livestock Genomics (CALG)
A coordinated international effort to sequence agricultural and livestock genomes has come to its time. While human genome and many other genomes related to human health and basic biological interests of many model organisms have been sequenced or plugged in the sequencing pipelines, a-gronomically important crop and livestock genomes have not been given to a high enough priority. Although we are facing many challenges in policy-making, grant funding, regional task emphasis , research community consensus and technology innovations, many initiatives are being announced and formulated based on the cost-effective and large-scale sequencing procedure, known as whole genome shotgun (WGS) sequencing that produces draft sequences covering a genome from. 95% to 99% . I- dentified genes from such draft genome, coupled with other resources, such as molecular markers, large-insert clones and cDNA sequences, provide ample information and tools to further our knowledge in agricultural and environmental biology in the genome era that just comes to its accelerated period. If the campaign succeeds , molecular biologists, geneticists and field biologists from all countries , rich or poor, would be brought to the same starting point and expect another astronomical increase of basic genomic information , ready to convert effectively the information into knowledge that will ultimately change our lives and environment into a greater and better future. We call upon attentions from national and international governmental agencies and organizations as well as research foundations to support this unprecedented movement.
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