T. Lupia, Alberto Gaviraghi, E. Concialdi, Maurizio Penna, S. Corcione, F. D. De Rosa
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Disseminated Cryptococcosis Complicating Severe SARS-CoV-2 Infection
Opportunistic invasive fungal infections (IFI) have been described in severe SARS-CoV-2 infection. COVID-19-related cytokine storm, immune dysregulation and lymphopenia may increase IFI susceptibility in comorbid patients. We described the case of a 64-year-old man with respiratory failure due to SARS-CoV-2 infection complicated with disseminated cryptococosis. We analyzed the role played by the SARS-CoV-2-associated lymphopenia and the cumulative risk factors that lead to secondary infection by Cryptococcus neoformans, and its part in the dysregulation of the immunity response.
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