对乙二醇毒性的有效乙醇率

Q3 Biochemistry, Genetics and Molecular Biology Turkish Computational and Theoretical Chemistry Pub Date : 2021-06-15 DOI:10.33435/tcandtc.813939
Faik Gökalp
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引用次数: 1

摘要

乙二醇(EG)是一种有毒物质,其代谢物可引起代谢性酸中毒。本研究的重点是在EG转化为其代谢物之前去除其毒性。用密度泛函方法研究了乙二醇与乙醇的相互作用。在血液中的乙二醇代谢物;乙醇酸更稳定,而整体不太稳定。研究了乙二醇与乙醇的相互作用对乙二醇代谢的影响。从乙二醇代谢物和乙醇中得到的热力学值也进行了分析。根据分析结果,乙醇和乙二醇的比例;最大有效点在血液中是非常稳定的,它的溶解度是由这个速率决定的。在预防中毒中,确定最适当的剂量是非常重要的。本研究在使用乙醇预防EG毒性方面是一项重要的研究,在其速率和防止时间和物质损失方面是第一次。
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The effective ethanol rate against the toxicity of ethylene glycol
Ethylene glycol (EG) is a toxic substance and EG metabolites cause metabolic acidosis. The major emphasis in this study is to get rid of the toxicity of EG before conversion to its metabolites. The interaction between ethylene glycol and ethanol has been studied using DFT (Density functional theory method). In ethylene glycol metabolites in the blood; Glycolic acid is more stable and gloxal less stable. The interaction of ethylene glycol with ethanol has been considered for ethylene glycol metabolism. Thermodynamic values obtained from ethylene glycol metabolites and ethanol were also analyzed. According to the analyst results of ethanol and ethylene glycol ratios; The maximum effective point is very stable in the blood and its solubility is determined at this rate. It is very important to determine the most appropriate rate in the prevention of toxicity. This study is an important study in terms of the use of ethanol in the prevention of toxicity of EG, the first of its rates and in terms of preventing the loss of time and substance.
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来源期刊
Turkish Computational and Theoretical Chemistry
Turkish Computational and Theoretical Chemistry Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
2.40
自引率
0.00%
发文量
4
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