儿童非酒精性脂肪性肝炎瞬时弹性成像(Fibroscan®)与超声和计算机层析成像分级的相关性

J. E. Lee, Kyung Ok Ko, J. Lim, E. Cheon, Young Hwa Song, J. Yoon
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引用次数: 4

摘要

目的本研究旨在探讨瞬时弹性成像(Fibroscan®)在诊断儿童和青少年非酒精性脂肪性肝炎方面的优势和有效性,并与腹部计算机断层扫描和肝脏超声检查进行比较。方法选取46名年龄在6 ~ 16岁的儿童和青少年,分别进行了瞬时弹性成像(Fibroscan®)、肝脏超声或腹部计算机断层扫描。39名参与者接受了肝脏超声检查,11名接受了计算机断层扫描。分析体格测量、血液检查结果、有无代谢综合征、肝脂肪变性和肝纤维化程度,并分析其与瞬时弹性成像(Fibroscan®)、腹部计算机断层扫描和肝脏超声检查的相关性,以及各检查之间的相关性。结果男性36例(78.3%),平均年龄12.29±2.57岁,平均体重指数27.88±4.28。在46名参与者中,天冬氨酸转氨酶、丙氨酸转氨酶和总胆红素的平均值分别为89.87±118.69 IU/L、138.54±141.79 IU/L和0.77±0.61 mg/dL。虽然瞬时弹性成像(Fibroscan®)和腹部计算机断层扫描分级与天冬氨酸转氨酶和丙氨酸转氨酶值有统计学意义的正相关,但瞬时弹性成像(Fibroscan®)、腹部计算机断层扫描和肝脏超声检查分级结果之间的相关性没有统计学意义。结论:我们证实每项检查都与一些血液检查结果相关,提示儿科瞬时弹性成像(Fibroscan®)诊断和治疗脂肪性肝炎的有效性和可能性。
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Correlation between Transient Elastography (Fibroscan®) and Ultrasonographic and Computed Tomographic Grading in Pediatric Nonalcoholic Steatohepatitis
Purpose This study aimed to examine the advantages and usefulness of transient elastography (Fibroscan®) in diagnosing non-alcoholic steatohepatitis in children and adolescents compared to those of abdominal computed tomography and liver ultrasonography. Methods Forty-six children and adolescent participants aged between 6 and 16 years who underwent transient elastography (Fibroscan®) as well as liver ultrasonography or abdominal computed tomography were included. Thirty-nine participants underwent liver ultrasonography and 11 underwent computed tomography. The physical measurements, blood test results, presence of metabolic syndrome, and the degree of liver steatosis and liver fibrosis were analyzed, and their correlations with transient elastography (Fibroscan®), abdominal computed tomography, and liver ultrasonography, as well as the correlations between examinations, were analyzed. Results Thirty-six participants (78.3%) were boys, and the mean age was 12.29±2.57 years, with a mean body mass index of 27.88±4.28. In the 46 participants, the mean values for aspartate aminotransferase, alanine aminotransferase, and total bilirubin were 89.87±118.69 IU/L, 138.54±141.79 IU/L, and 0.77±0.61 mg/dL, respectively. Although transient elastography (Fibroscan®) and abdominal computed tomography grading had a statistically significant positive correlation with aspartate aminotransferase and alanine aminotransferase values, the correlations between the results of grading performed by transient elastography (Fibroscan®), abdominal computed tomography, and liver ultrasonography were not statistically. Conclusion We confirmed that each examination was correlated with the results of some blood tests, suggesting the usefulness and possibility of diagnosis and treatment of steatohepatitis mediated by transient elastography (Fibroscan®) in the department of pediatrics.
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来源期刊
CiteScore
3.90
自引率
0.00%
发文量
43
期刊介绍: Pediatric Gastroenterology, Hepatology and Nutrition (Pediatr Gastroenterol Hepatol Nutr), an official journal of The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition, is issued bimonthly and published in English. The aim of Pediatr Gastroenterol Hepatol Nutr is to advance scientific knowledge and promote child healthcare by publishing high-quality empirical and theoretical studies and providing a recently updated knowledge to those practitioners and scholars in the field of pediatric gastroenterology, hepatology and nutrition. Pediatr Gastroenterol Hepatol Nutr publishes review articles, original articles, and case reports. All of the submitted papers are peer-reviewed. The journal covers basic and clinical researches on molecular and cellular biology, pathophysiology, epidemiology, diagnosis, and treatment of all aspects of pediatric gastrointestinal diseases and nutritional health problems.
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