内剂量学:技术现状和研究需要

Pub Date : 2022-12-30 DOI:10.14407/jrpr.2021.00297
F. Paquet
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引用次数: 0

摘要

内剂量学是一门学科,它汇集了一套知识、工具和程序,用于计算放射性核素进入人体后所接受的剂量。计算工作人员或公众的承诺有效剂量需要几个步骤。每个步骤都使用了放射性核素生物动力学、器官和组织中的能量沉积、辐射引起随机效应的效率或单个器官和组织对辐射总体损害的贡献等领域的最佳知识。在所有这些领域中,知识都是丰富的,并且有许多几十年前开始的工作作为支撑。这使得CED成为一个非常可靠的量,代表了参考人员在参考照射情况下的照射,并用于优化和评估对剂量限值的遵守情况。但是,由于简化的原因,国际放射防护委员会(ICRP)接受了CED的某些限制。它的一些局限性值得克服,ICRP正在为此不断努力。除了努力使CED成为更加可靠和精确的工具之外,个性化剂量测定的需求也在不断增加,特别是在医疗领域。为了满足这一需求,可以调整目前可用的剂量学工具。然而,这需要将这些努力与更好地评估个人风险结合起来,这样就必须考虑到有关人员的生理状况,以及他们的生活方式和病史。剂量学和风险评估密切相关,只能并行发展。本文介绍了内剂量学知识的现状和需要克服的限制,以便使CED更精确,并发展其他剂量学量,从而可能更好地近似个体剂量。
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Internal Dosimetry: State of the Art and Research Needed
Internal dosimetry is a discipline which brings together a set of knowledge, tools and procedures for calculating the dose received after incorporation of radionuclides into the body. Several steps are necessary to calculate the committed effective dose (CED) for workers or members of the public. Each step uses the best available knowledge in the field of radionuclide biokinetics, energy deposition in organs and tissues, the efficiency of radiation to cause a stochastic effect, or in the contributions of individual organs and tissues to overall detriment from radiation. In all these fields, knowledge is abundant and supported by many works initiated several decades ago. That makes the CED a very robust quantity, representing exposure for reference persons in reference situation of exposure and to be used for optimization and assessment of compliance with dose limits. However, the CED suffers from certain limitations, accepted by the International Commission on Radiological Protection (ICRP) for reasons of simplification. Some of its limitations deserve to be overcome and the ICRP is continuously working on this. Beyond the efforts to make the CED an even more reliable and precise tool, there is an increasing demand for personalized dosimetry, particularly in the medical field. To respond to this demand, currently available tools in dosimetry can be adjusted. However, this would require coupling these efforts with a better assessment of the individual risk, which would then have to consider the physiology of the persons concerned but also their lifestyle and medical history. Dosimetry and risk assessment are closely linked and can only be developed in parallel. This paper presents the state of the art of internal dosimetry knowledge and the limitations to be overcome both to make the CED more precise and to develop other dosimetric quantities, which would make it possible to better approximate the individual dose.
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