亲水性聚甲基丙烯酸羟乙酯与疏水性聚氨酯、聚氯乙烯膜茶碱渗透性的比较

Reactive Polymers Pub Date : 1994-11-01 DOI:10.1016/0923-1137(94)90137-6

M. Pulat

{"title":"亲水性聚甲基丙烯酸羟乙酯与疏水性聚氨酯、聚氯乙烯膜茶碱渗透性的比较","authors":"M. Pulat","doi":"10.1016/0923-1137(94)90137-6","DOIUrl":null,"url":null,"abstract":"<div><p>In this study, the diffusion characteristics of theophylline through polyurethane (PU), polyvinylchloride (PVC) and polyhydroxyethylmethacrylate (PHEMA) membranes were investigated for their usage as oral controlled-release reservoir systems. PU and PVC membranes were prepared by the solvent-casting method and PHEMA membrane was prepared by bulk polymerization of 2-hydroxyethylmethacrylate in different thicknesses. Diffusion measurements were performed in simulated gastric fluid and simulated intestinal fluid during 10 h at 37°C using a diffusion cell. Permeability coefficients calculated from diffusion experiments were found to be approximately 10 times higher in PHEMA than PU and PVC membranes.</p></div>","PeriodicalId":20864,"journal":{"name":"Reactive Polymers","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1994-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0923-1137(94)90137-6","citationCount":"8","resultStr":"{\"title\":\"The comparison of theophylline permeabilities from hydrophilic polyhydroxyethylmethacrylate and hydrophobic polyurethane, polyvinylchloride membranes\",\"authors\":\"M. Pulat\",\"doi\":\"10.1016/0923-1137(94)90137-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this study, the diffusion characteristics of theophylline through polyurethane (PU), polyvinylchloride (PVC) and polyhydroxyethylmethacrylate (PHEMA) membranes were investigated for their usage as oral controlled-release reservoir systems. PU and PVC membranes were prepared by the solvent-casting method and PHEMA membrane was prepared by bulk polymerization of 2-hydroxyethylmethacrylate in different thicknesses. Diffusion measurements were performed in simulated gastric fluid and simulated intestinal fluid during 10 h at 37°C using a diffusion cell. Permeability coefficients calculated from diffusion experiments were found to be approximately 10 times higher in PHEMA than PU and PVC membranes.</p></div>\",\"PeriodicalId\":20864,\"journal\":{\"name\":\"Reactive Polymers\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1994-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0923-1137(94)90137-6\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Reactive Polymers\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0923113794901376\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reactive Polymers","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0923113794901376","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 8

摘要

本研究考察了茶碱在聚氨酯(PU)、聚氯乙烯(PVC)和聚甲基丙烯酸羟乙酯(PHEMA)膜上作为口服控释储层的扩散特性。采用溶剂浇铸法制备PU和PVC膜，采用不同厚度的2-羟乙基甲基丙烯酸酯本体聚合法制备PHEMA膜。在37°C下，使用扩散池在模拟胃液和模拟肠液中进行10小时的扩散测量。通过扩散实验计算的渗透系数发现，PHEMA比PU和PVC膜高约10倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

The comparison of theophylline permeabilities from hydrophilic polyhydroxyethylmethacrylate and hydrophobic polyurethane, polyvinylchloride membranes

In this study, the diffusion characteristics of theophylline through polyurethane (PU), polyvinylchloride (PVC) and polyhydroxyethylmethacrylate (PHEMA) membranes were investigated for their usage as oral controlled-release reservoir systems. PU and PVC membranes were prepared by the solvent-casting method and PHEMA membrane was prepared by bulk polymerization of 2-hydroxyethylmethacrylate in different thicknesses. Diffusion measurements were performed in simulated gastric fluid and simulated intestinal fluid during 10 h at 37°C using a diffusion cell. Permeability coefficients calculated from diffusion experiments were found to be approximately 10 times higher in PHEMA than PU and PVC membranes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助