球形吸着炭 (クレメジン原体) の吸着特性に関する検討

The adsorption characteristics of various adsorbates by spherical charcoal (Kremezin ®) were studied in vitro and then compared with those of powdered medical charcoal. Medical charcoal adsorbs substances with molecular weights ranging from several hundred daltons to several thousand daltons. Kremezin, however, adsorbs only low molecular weight substances with molecular weights of up to several hundred daltons. Therefore, the adsorption selectivity of Kremezin, which is related to the molecular weight of adsorbate, seemed to contribute to the specific pharmacological action of this drug under clinical conditions. In batch adsorption tests for various amines, amino acids and organic acids with molecular weightsof from 45 to 251, both adsorbents showed similar behaviors. An increase in the size of the adsorbate molecule enhanced the degree of adsorption, especially in compounds that are analogs. The molecular structure also seemed to be an important factor in the adsorption phenomena; an aromatic ring tended to increase the adsobability while the amino group, carboxyl group and hydroxyl group all showed a decrease in adsorbability.