智利精神分裂症患者il - 6r基因Asp358Ala变异(rs2228145)、IL-6血浆水平和氯氮平治疗抵抗之间缺乏相关性

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2019-06-25 DOI:10.1155/2019/5601249
Álvaro Cavieres, C. Campos-Estrada, Y. Moya, Rocío Maldonado, R. González-Vargas, M. Bustamante, P. Moya
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引用次数: 3

摘要

神经炎症过程的改变被认为有助于精神分裂症的发展(SZ);与这种疾病有关的炎症系统的一个组成部分是白细胞介素-6 (IL-6)。rs2228145的次要等位基因是IL-6受体基因的一种功能多态性,与IL-6血浆水平升高和炎症活性增加有关,这使其成为SZ临床异质性的一个有趣的候选因素。我们研究了100名接受氯氮平治疗的患者。用简易精神病评定量表对患者的症状进行量化;将得分最低(“缓解”)的患者与得分最高(“氯氮平治疗抵抗”)的患者进行比较。我们测定了rs2228145和IL-6血浆水平的等位基因频率。我们的结果不支持IL-6在氯氮平治疗反应中的作用。考虑潜在的混杂因素的进一步研究是必要的。
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Lack of Association between the IL6R Gene Asp358Ala Variant (rs2228145), IL-6 Plasma Levels, and Treatment Resistance in Chilean Schizophrenic Patients Treated with Clozapine
Alterations in neuroinflammatory processes have been suggested to contribute to the development of Schizophrenia (SZ); one component of the inflammatory system that has been linked to this disorder is interleukin-6 (IL-6). The minor allele of rs2228145, a functional polymorphism in the IL-6 receptor gene, has been associated to elevated IL-6 plasma levels and increased inflammatory activity, making it an interesting candidate to study as a possible factor underlying clinical heterogeneity in SZ. We studied a sample of 100 patients undergoing treatment with clozapine. Their symptoms were quantified by Brief Psychotic Rating Scale; those with the lowest scores (“remitted”) were compared with the highest (“clozapine treatment resistant”). We determined allelic frequencies for rs2228145 and IL-6 plasma levels. Our results do not support a role of IL-6 in response to treatment with clozapine. Further studies accounting for potential confounding factors are necessary.
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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