Anti-Irritants: Myth or Reality? An Overview

Anti-irritants, whether naturally occurring or man-made, are substances that provide a soothing effect to irritated skin and reduce damage by a variety of mechanisms, including reduced absorption and/or biochemical manipulation of noxious chemicals. These products show promise in reducing irritation caused by acute and chronic exposure to known irritant chemicals; however, the data on anti-irritants are incomplete. Controlled trials of the efficacy of proposed anti-irritants substances in reducing irritant contact dermatitis in human and animal models are reviewed. Based on our literature and hand search, anti-irritants seem promising in treating and preventing a variety of irritant contact dermatitis conditions, but their true effects remain sub judice. Many studies do not allow deduction of clinical effects. Further experimentation must be performed to assess sensitivity and specificity of each anti-irritant to their specific irritant-inducing substance.