维生素C、替扎尼定和普瑞巴林对氟哌啶醇诱导的帕金森大鼠抗帕金森活性的评价

P. Patil, V. Chaware, A. Thorat, V. Redasani
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摘要

本研究探讨左旋多巴/卡比多巴、维生素C、替扎尼定、普瑞巴林对氟哌啶醇(1mg /kg i.p)诱导的帕金森大鼠的抗帕金森作用。氟哌啶醇1mg/kg灌胃诱导ⅱ、ⅲ、IV、V、VI、VII、VIII组动物神经退行性变。阳性对照(iii组)左旋多巴/卡比多巴(125 mg/kg p.o),试验1 (-IV组)维生素C (120mg/kg p.o),试验2 (v组)替扎尼定(0.3 mg/kg i.p),试验3 (-VI组)普瑞巴林(30 mg/kg p.o),试验4 (vii组)每日给予维生素C(120 mg/kg p.o)和替扎尼定(0.3 mg/kg i.p)治疗,试验5 (viii组)每日给予维生素C(120 mg/kg p.o)和普瑞巴林(30mg/kg p.o)治疗,并在氟哌啶醇攻毒前30 min,连续14 d。记录第14天的行为学参数,分别进行高棒试验、视压计试验、旋转棒试验。同时记录MDA和多巴胺水平。测试4(组- VII)显示更显著的镇痛评分降低。在actoptopometer上,测试4 (vii组)显示运动活动显著增加。在旋转棒试验中,试验2 (v组)和试验4 (vii组)的运动协调活动增加更为显著。左旋多巴/卡比多巴的多巴胺水平升高更为显著,且显著降低了催眠评分。维生素C对MDA水平的降低作用更为显著。结论:替扎尼定和普瑞巴林可能具有抗帕金森活性。维生素C与替扎尼定可能具有协同作用。提示替扎尼定和普瑞巴林可用于改善帕金森病的僵直性。
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Evaluation of Antiparkinson Activity of Vitamin C, Tizanidine and Pregabalin against Haloperidol Induced Parkinsonism in Rats
The present study deals with the antiparkinson effect of Levodopa/carbidopa, Vitamin C, Tizanidine, Pregabalin on haloperidol (1 mg/kg i.p) induced Parkinsonism in rats. Neural degeneration was induced in animals (Group II, III, IV, V, VI, VII, VIII) by i.p. administration of haloperidol at 1mg/kg. Positive control (Group-III) treated by levodopa/carbidopa  (125 mg/kg p.o.), Test 1 (Group -IV) treated by vitamin C (120mg/kg p.o.), Test 2 (Group-V) treated by Tizanidine  (0.3 mg/kg i.p.), Test 3 (Group -VI) treated by Pregabalin  (30 mg/kg p.o.), Test 4 (Group-VII) treated by Vitamin C(120 mg/kg p.o.) and  Tizanidine (0.3 mg/kg i.p.) and Test 5 (Group-VIII) treated by Vitamin C(120 mg/kg p.o.) and  Pregabalin (30mg/kg p.o) daily were given before 30 min of haloperidol challenged for 14 days. Behavioural parameters were recorded on day 14 for high bar test, actophotometer test, rotarod test. MDA level and Dopamine level were also recorded. Test 4 (Group- VII) showed more significant reduction in cataleptic score. In actophotometer, Test 4 (Group-VII) showed significant increase in locomotor activity. In rotarod test, Test 2 (Group-V) and test 4 (Group-VII) showed more significant increase motor coordination activity. Levodopa/Carbidopa showed more significant increase in dopamine level and significantly abolished cataleptic score. Vitamin C showed more significant decrease in MDA level. It can be concluded that the tizanidine and pregabalin may possess antiparkinsonian activity. Vitamin C and tizanidine may possess synergestic effect. These results showed that tizanidine and pregabalin may be used to improve catalepsy in Parkinson disease.
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