Formulation and Characterization of Tranylcypromine loaded Polymeric Micellar In-Situ Nasal Gel for treatment of Depression

:Tranylcypromine is a drug used as antidepressant,anxiolytic, nonselective MAO A/B inhibitor. This drug is used to treat depression.The research was conducted to develop a polymeric micelle using a block copolymer, Pluronic F-68 and Gelucire 50/13 to improve the permeability of Tranylcypromine (TCP). A direct dissolution method was used to prepare polymeric micelles. The prepared micelles were characterised for particle size, % EE, zeta potential, in-vitro release. These micelles solution was used to prepare in situ gel by cold method in order to achieve controlled release. Central composite design was used for optimization of both polymeric micelles and insitu nasal gel.The main objective of this research work is to develop formulation acting centrally without undergoing first pass metabolism i.ie. directly nasal to brain delivery route.