基于Bi(III)的新型协同复合体:小儿肺炎的治疗与护理应用价值

IF 2.1 4区 化学 Q3 CHEMISTRY, PHYSICAL Progress in Reaction Kinetics and Mechanism Pub Date : 2021-01-01 DOI:10.1177/14686783211045834
Jianli Lu, H. Han, Bo Li, Yanjun Han
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引用次数: 0

摘要

本研究采用混合配体生成方法,通过2,2′-联吡啶(2,2′-bpy)与[Bi4Cl8(PDC)2(2,2′-bpy)4]·2MeCN(1)之间的溶剂热反应合成了新鲜铋(III)有机化合物;2,6-吡啶二羧酸;还有氯化铋。结构表征结果表明,配合物1具有双核离散结构,并通过π -π相互作用进一步扩展为一维链状超分子网络。进一步探讨该化合物对小儿肺炎的治疗和护理应用价值,并探讨该新型化合物的作用机制。首先,在我们的研究中,采用酶联免疫吸附试验(ELISA)检测试剂盒测定肺泡灌洗液中释放的炎性细胞因子含量。随后,利用实时逆转录-聚合酶链反应(RT-PCR)探索了肺泡上皮细胞中腺苷5 ' -单磷酸腺苷(AMP)激活蛋白激酶(AMPK)信号通路的激活。分子对接表明,虽然Bi配合物中存在多个吡啶环,但只观察到羧酸基与活性残基相互作用。
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A new Bi(III)-based coordination complex: Treatment and nursing application values on pediatric pneumonia
In the current work, through applying the mixed-ligand generation method, [Bi4Cl8(PDC)2 (2,2′-bpy)4]·2MeCN (1), a fresh bismuth (III)-organic compound synthesized with the solvothermal reactions between 2,2′-bipyridine (2,2′-bpy); 2,6-pyridinedicarboxylic acid (H2PDC); and bismuth chloride. The structural characterization results show that complex 1 features a binuclear discrete structure which is further extended into a 1D chain–like supramolecular network via π–π interactions. Furthermore, the compound’s treatment and nursing application values on pediatric pneumonia was explored and the novel compound’s corresponding mechanism was also investigated. First of all, in our research, the enzyme-linked immunosorbent assay (ELISA) detection kit was employed for the determination of the inflammatory cytokines content released into alveolar lavage fluid. Subsequently, the adenosine 5‘-monophosphate (AMP)–activated protein kinase (AMPK) signaling pathway activation in alveolar epithelial cells was explored exploiting the real-time reverse transcription–polymerase chain reaction (RT-PCR). Molecular docking demonstrated that although multiple pyridine rings are presented in the Bi complex, however, only the carboxylate groups have been observed to interact with the active residues.
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来源期刊
CiteScore
2.10
自引率
0.00%
发文量
5
审稿时长
2.3 months
期刊介绍: The journal covers the fields of kinetics and mechanisms of chemical processes in the gas phase and solution of both simple and complex systems.
期刊最新文献
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