The magic particle silica: Past to present

The challenges in the field of chromatographic separation mainly fast and efficient separation for variety of samples has led to the changes in particle size, improvement in packing material design, development of synthetic method has provided the possibility of fabricating silica nanoparticle with different sizes in nanometer ranges. In present review, we have tried to show the journey of silica particle over the years and changes in the size, surface, internal pore size and packings. Their applications especially the mesoporous nanoparticles have also been mentioned.