口腔给药用黏附成膜喷雾剂的研究进展

Reem Wael Shahadha, Nidhal Khazaal Maraie
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引用次数: 0

摘要

与传统的局部治疗相比,成膜喷雾剂具有许多优点,包括均匀的药物分布和剂量,增加生物利用度(增加局部药物浓度)和更少的刺激性(给药频率)。聚合物和赋形剂改善了制剂的特性,增加了活性物质的稳定性,是粘接成膜喷雾剂的基本组成部分。由聚合物和赋形剂的不同组合制成的薄膜表现出广泛的特性。本文综述了聚合物和赋形剂的多种类型,不同类型的喷雾器,不同的评价方法,以及定义可喷涂性和薄膜性能的基本标准。由此得出结论,具有粘弹性的天然聚合物和合成聚合物都可以用于优化口腔药物的给药。
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Mucoadhesive Film Forming Spray for Buccal Drug Delivery: A Review
Film-forming sprays provide a number of advantages over conventional topical treatments, including equal medication distribution and dosing, increased bioavailability (increase local drug concentration), and less irritability (Dosing frequency). Polymers and excipients that improve the characteristics of preparations and increase the stability of active substances are the building blocks of mucoadhesive film-forming sprays. Films made from diverse combinations of polymer and excipient exhibited a wide range of characteristics. This reveiw examines the many types of polymers and excipients, the different types of sprayers, the different evaluations, as well as the essential criteria that are involved in defining the sprayability and film properties. This comes to the conclusion that natural and synthetic polymers with viscoelastic properties can both be employed to optimize the administration of buccal drugs.
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