基于免疫组织化学分析的治疗方案对乳腺癌患者血象的评价:一项回顾性研究

Nidda Saeed, F. Pervaiz, S. Manzoor, Muhammad Ali, S. Saleem, Saliha Khalid, F. M. Khan, S. A. Ali, Z. Hussain, Nadeem Bhattee
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引用次数: 0

摘要

为了评估影响乳腺癌患者血液化学的激素受体状态的普遍性、结论和治疗方案,巴基斯坦巴哈瓦尔普尔核与肿瘤研究所(BINO)进行了一项回顾性研究,根据数据的可用性,180名乳腺癌患者参加了这项研究。收集患者的人口统计数据、肿瘤的部位、分期和分级;激素状态;治疗策略;雌激素(ER)、孕激素(PR)和人表皮生长因子受体2 (Her-2/Neu)受体;血液化学报告,包括TLC(总白细胞计数),TRC(总红细胞计数),血红蛋白,血小板和肌酐;化疗引起的不良反应。采用SPSS version 20对数据进行统计分析。大多数乳腺癌患者年龄在41岁至60岁之间,一半的患者患有右乳癌。结果预测女性出现在III期的比例为57%。绝经后妇女(63.97%)比绝经前妇女(36.03%)更易患病。50%的患者ER/PR阳性,23%的患者三重阳性。化疗是为激素阴性的病人开的,而激素治疗是为激素负责的肿瘤开的。Her-2阳性患者给予单克隆抗体治疗。治疗策略直接影响患者的血象,但对一些患者没有影响。TLC、TRC、血红蛋白和血小板计数轻微下降导致贫血、免疫力低下、厌食症、体重减轻、中性粒细胞减少和血小板减少,而肌酐水平升高导致肾毒性。报告有药物不良反应的患者,如疼痛、发烧、呕吐、脱发、厌食和嗜睡,被建议改变生活方式,特别强调饮食建议,以解决这些问题。乳腺癌治疗导致正常血象值的破坏,并导致骨髓抑制,这从患者出现的副作用中可以明显看出。建议对这种致命疾病进行营养咨询,以提高他们的生活质量。
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Evaluation of the Hemogram of Breast Cancer Patients Treated by Therapeutic Protocol Based on Immunohistochemical Analysis: A Retrospective Study
To gauge the pervasiveness, verdict, and treatment protocols related to hormone receptor status effecting blood chemistry in breast cancer patients, a retrospective study was conducted at the Bahawalpur Institute of Nuclear and Oncology (BINO), Pakistan. 180 breast cancer patients were enrolled in the study on the basis of data availability. Data was collected about patient’s demographics, site, stage and grade of tumour; hormonal status; treatment strategy; Estrogen (ER), Progesterone (PR) and Human Epidermal growth factor receptor 2 (Her-2/Neu) receptors; Blood chemistry reports including TLC (Total Leukocyte Count), TRC (Total RBC Count), Haemoglobin, Platelets and Creatinine; and ADRs due to chemotherapy. SPSS version 20 was used for statistical analysis of the data. Majority of patients become victim of breast cancer were belonging to age group of 41 to 60 years and half patients had carcinoma of the right breast. Results predict that females present at Stage III was 57%. Pos-tmenopausal women were highly susceptible to disease (63.97%) than pre-menopausal (36.03%). ER/PR positive status was in 50% patients while 23% patients had triple positive status. Chemotherapy was prescribed for hormone negative status patients whereas hormone therapy was preffered for hormone responsible tumours. Her-2 positive status patients were given monoclonal antibody therapy. Treatment strategies directly affected the hemogram of patients while remain un-affected in some patients. Slight decline was observed in TLC, TRC, haemoglobin and platelet count that caused anaemia, poor immunity, anorexia, weight loss, neutropenia and thrombocytopenia whereas elevation in creatininelevel resulted in nephrotoxicity. Patients reported with Adverse Drug Reactions i.e. pain, fever, vomiting, hair loss, anorexia and lethargy were counselled for the life style modifications with special emphasis on dietary recommendations for combating the problems. Breast cancer therapy caused disruption of the normal hemogram values and resulted in bone marrow suppression that was evident from side effects appearence in patients. Nutritional counseling of this fatal disease is recommended for improving their quality of life.
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