Synthesis And Anti Microbial Studies Of Certain Schiff Bases Containing 1,8-Naphthyridine Moiety

Keeping in view of the biological potential of Schiff bases attached to heterocyclic ring system the synthesis of certain Schiff bases containing 1,8-naphthyridines were undertaken.2-amino nicotinaldehyde on condensation with ethyl cyano acetate yielded 2-hydroxy-3-cyano-1,8-naphthyridine.(I) This upon treatment with 10% NaoH solution gave 2-hydroxy-1,8naphthyridine-3-carboxylic acid. (II). Compound II on treatment with phosphorus oxy chloride gave 2-chloro-1,8-naphthyridine-3carboxylic acid.(III). The compound (III) upon treatment with hydrazine hydrate in ethanol gave 2-hydrazido-1,8-naphthyridine-3carboxylic acid. (Va-d) which are schiff’s bases. The schiff’s bases on treatment with trietyhl amine in dry 1,4-dioxan and mono chloro acetyl chloride yielded 3-chloro-4-(substituted phenyl)-1-(3-carboxy-1,8-naphthyridin-2-yl amino)-azetidin-2-one.(Via-d). The constitution of all compounds synthesized was established by elemental analysis and spectral studies. Allcompounds were evaluated for antibacterial and antifungal activites against different strains of bacterial and fungal organisms. Some of the compounds exhibited significant anti bacterial activity.