【慢性下肢缺血合并冠心病患者联合治疗的即时效果】。

B G Alekyan, A V Pokrovsky, A E Zotikov, N G Karapetyan, A V Chupin, A B Varava, Yu B Knysh, A Ya Novak, M A Sedgaryan
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摘要

下肢动脉疾病的发病率逐年上升。根据世界文献资料,该疾病的进展可导致院内和远程期间发生主要不良心血管事件,下肢严重缺血以及截肢。治疗慢性下肢缺血的主要目的不仅是挽救下肢,而且是降低该患者队列的心血管风险。我们的研究是为了分析各种治疗策略对IIB期慢性下肢缺血合并冠状动脉疾病患者的疗效。共纳入87例患者。根据治疗方案分为两组:1组41例(47.1%)采用分阶段血管内放射治疗(经皮冠状动脉介入治疗、下肢动脉支架置入术和成形术),2组46例(52.9%)采用分阶段联合治疗(经皮冠状动脉介入治疗和下肢动脉开放手术)。本研究的目的是探讨慢性下肢缺血伴冠状动脉疾病患者经皮冠状动脉介入治疗和下肢动脉开放手术联合治疗的住院疗效。2组46例患者共接受111例手术,其中下肢动脉一期开放手术53例,经皮冠状动脉介入手术58例,无死亡、急性心肌梗死、急性脑缺血/短暂性脑缺血发作或出血等重大心血管不良事件,发生分流血栓形成1例(2.1%)。
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[Immediate results of combined treatment of patients with chronic lower limb ischemia and concomitant coronary artery disease].

The incidence of lower-extremity arterial disease is growing year after year. According to the world literature data, progression of the disease leads to the development of major adverse cardiovascular events during both in-hospital and remote periods, to critical ischaemia of lower limbs, as well as to amputations. The primary purpose of treatment of chronic lower limb ischemia is not only to save the lower extremities but also to reduce the cardiovascular risk in this patient cohort. Our study was undertaken to analyse the efficacy of various strategies of treatment of patients with stage IIB chronic lower-limb ischemia combined with coronary artery disease. It included a total of 87 patients. Depending on the therapeutic policy chosen, they were divided into two groups: Group 1 consisted of 41 (47.1%) patients undergoing staged roentgenendovascular treatment (percutaneous coronary intervention, stenting and angioplasty of lower-limb arteries) and Group 2 comprised 46 (52.9%) patients subjected to staged combined treatment (percutaneous coronary intervention and open surgery of lower-limb arteries). The purpose of the present study was to examine the in-hospital outcomes of combined treatment: percutaneous coronary intervention and open surgical operations on arteries of lower limbs in patients with chronic lower-limb ischemia and accompanying coronary artery disease. The forty-six Group 2 patients endured a total of 111 operations: 53 primary open operations on lower-limb arteries and 58 percutaneous coronary interventions, followed by no major adverse cardiovascular events such as death, acute myocardial infarction, acute cerebral ischemia/transient ischemic attack or hemorrhage, with 1 (2.1%) major adverse limb event in the form of shunt thrombosis encountered.

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