Shao Ling, Y. Shu, Chen Ceying, Du Min, Li Yan, Z. Song
{"title":"光学相干断层血管造影在黄斑变性治疗及随访中的作用","authors":"Shao Ling, Y. Shu, Chen Ceying, Du Min, Li Yan, Z. Song","doi":"10.3760/CMA.J.ISSN.2095-1477.2019.11.012","DOIUrl":null,"url":null,"abstract":"Objective \nTo evaluate the role of optical coherence tomographic angiography(OCTA) in anti-vascular endothelial growth factor(VEGF) treating the neovascular age-related macular degeneration(nAMD) and follow-up. \n \n \nMethods \nTotal of 41 eyes of 33 patients with nAMD in the Second People’s Hospital of Zhengzhou from May 2018 to Oct. 2018 were analyzed retrospectively. All cases were treated with intravitreal injection of ranibizumab(IVR). All cases were followed up for 6 months. \n \n \nResults \nAt 6 months after treatment, the OCT and OCTA showed the average central retinat thickness reduced (t=31.454, P=0.000), and CNV flow areas shrinked after IVR(t=4.117, P=0.000). The decrease of CNV flow areas in eyes with dense-network CNV was more obvious than that in loose-network CNV (Z=3.686, P=0.000). \n \n \nConclusion \nOCTA is a reliable method to observe dynamically the strutures and quantified the blood flow area of CNV. It is significant in treatment and follow-up evaluation of nAMD. \n \n \nKey words: \nDegeneration, macular, age-related, neovascular; Angiography, OCT; Therapy, anti-VEGF","PeriodicalId":10126,"journal":{"name":"中华眼外伤职业眼病杂志","volume":"20 1","pages":"857-861"},"PeriodicalIF":0.0000,"publicationDate":"2019-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of optical coherence tomographic angiography in the treatment and follow-up of macular degeneration\",\"authors\":\"Shao Ling, Y. Shu, Chen Ceying, Du Min, Li Yan, Z. Song\",\"doi\":\"10.3760/CMA.J.ISSN.2095-1477.2019.11.012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo evaluate the role of optical coherence tomographic angiography(OCTA) in anti-vascular endothelial growth factor(VEGF) treating the neovascular age-related macular degeneration(nAMD) and follow-up. \\n \\n \\nMethods \\nTotal of 41 eyes of 33 patients with nAMD in the Second People’s Hospital of Zhengzhou from May 2018 to Oct. 2018 were analyzed retrospectively. All cases were treated with intravitreal injection of ranibizumab(IVR). All cases were followed up for 6 months. \\n \\n \\nResults \\nAt 6 months after treatment, the OCT and OCTA showed the average central retinat thickness reduced (t=31.454, P=0.000), and CNV flow areas shrinked after IVR(t=4.117, P=0.000). The decrease of CNV flow areas in eyes with dense-network CNV was more obvious than that in loose-network CNV (Z=3.686, P=0.000). \\n \\n \\nConclusion \\nOCTA is a reliable method to observe dynamically the strutures and quantified the blood flow area of CNV. It is significant in treatment and follow-up evaluation of nAMD. \\n \\n \\nKey words: \\nDegeneration, macular, age-related, neovascular; Angiography, OCT; Therapy, anti-VEGF\",\"PeriodicalId\":10126,\"journal\":{\"name\":\"中华眼外伤职业眼病杂志\",\"volume\":\"20 1\",\"pages\":\"857-861\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-11-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华眼外伤职业眼病杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.2095-1477.2019.11.012\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华眼外伤职业眼病杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.2095-1477.2019.11.012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The role of optical coherence tomographic angiography in the treatment and follow-up of macular degeneration
Objective
To evaluate the role of optical coherence tomographic angiography(OCTA) in anti-vascular endothelial growth factor(VEGF) treating the neovascular age-related macular degeneration(nAMD) and follow-up.
Methods
Total of 41 eyes of 33 patients with nAMD in the Second People’s Hospital of Zhengzhou from May 2018 to Oct. 2018 were analyzed retrospectively. All cases were treated with intravitreal injection of ranibizumab(IVR). All cases were followed up for 6 months.
Results
At 6 months after treatment, the OCT and OCTA showed the average central retinat thickness reduced (t=31.454, P=0.000), and CNV flow areas shrinked after IVR(t=4.117, P=0.000). The decrease of CNV flow areas in eyes with dense-network CNV was more obvious than that in loose-network CNV (Z=3.686, P=0.000).
Conclusion
OCTA is a reliable method to observe dynamically the strutures and quantified the blood flow area of CNV. It is significant in treatment and follow-up evaluation of nAMD.
Key words:
Degeneration, macular, age-related, neovascular; Angiography, OCT; Therapy, anti-VEGF
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