治疗的主要方式将会改变:转移性肾细胞癌的中低危患者不再需要减量肾切除术

I. Tsimafeyeu
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摘要

迄今为止,对于可能手术切除的原发性肾细胞癌(RCC)和多发转移的患者,通常推荐在全身治疗前进行细胞减减性肾切除术。酪氨酸激酶抑制剂的靶向治疗被广泛应用于转移性肾细胞癌的一线治疗。CARMENA研究的目的是确定转移性肾细胞癌(mRCC)患者在开始靶向治疗前是否需要进行细胞减少手术。
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The Mainstay of Treatment will be Changed: Cytoreductive Nephrectomy Would Not be Required in Intermediate and Poor Risk Patients with Metastatic Renal Cell Carcinoma Cancer
To date, cytoreductive nephrectomy before systemic therapy is generally recommended in patients with a potentially surgically resectable primary renal cell carcinoma (RCC) and multiple metastases. Targeted therapy with tyrosine kinase inhibitors is widely used in the firstline treatment of metastatic renal cell carcinoma. The objective of CARMENA study was to determine whether cytoreductive surgery before the initiation of the targeted therapy in patients with metastatic renal cell carcinoma (mRCC) is required.
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