估计脊髓灰质炎病毒免疫球蛋白G抗体水平在健康,超重和肥胖儿童

Shimaa Ahmed Mohammed, Hoda Seoud, Marwa Elhady, Asmaa S Hassan
{"title":"估计脊髓灰质炎病毒免疫球蛋白G抗体水平在健康,超重和肥胖儿童","authors":"Shimaa Ahmed Mohammed, Hoda Seoud, Marwa Elhady, Asmaa S Hassan","doi":"10.4103/sjamf.sjamf_104_21","DOIUrl":null,"url":null,"abstract":"Background Obesity is a disease of multiple complex causes, leading to accumulation of excess body fat owing to imbalance between energy intake and output. Adiposity produces a state of chronic inflammation that adversely affects the immune system, which could affect the response to vaccination. Aim To evaluate the effect of overweight and obesity on the polio-specific immunoglobulin G antibodies (anti-polio immunoglobulin G) production in a sample of Egyptian children. Patients and methods This case–control study was conducted at Al Azhar University Hospital from February 2019 to February 2020. It included 150 children, aged 24 months. According to BMI centiles, they were classified into three groups: obese group and overweight group, each included 45 children, and 60 nonobese age-matched and sex-matched healthy controls. All children fulfilled both the obligatory vaccination schedule as well as additional doses. Assessment of anti-polio antibody production was done using qualitative enzyme immunoassay technique kits. Results A significantly higher anti-polio antibody production was observed in nonobese group compared with both obese and overweight children. Additional doses of polio vaccine were associated with a significant increase in antibody titer in healthy children but not in either overweight or obese children. Conclusion Obesity and overweight adversely affect the antibody production against polio vaccine.","PeriodicalId":22975,"journal":{"name":"The Scientific Journal of Al-Azhar Medical Faculty, Girls","volume":"39 1","pages":"555 - 559"},"PeriodicalIF":0.0000,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Estimation of poliovirus immunoglobulin G antibodies level in the healthy, overweight, and obese children\",\"authors\":\"Shimaa Ahmed Mohammed, Hoda Seoud, Marwa Elhady, Asmaa S Hassan\",\"doi\":\"10.4103/sjamf.sjamf_104_21\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background Obesity is a disease of multiple complex causes, leading to accumulation of excess body fat owing to imbalance between energy intake and output. Adiposity produces a state of chronic inflammation that adversely affects the immune system, which could affect the response to vaccination. Aim To evaluate the effect of overweight and obesity on the polio-specific immunoglobulin G antibodies (anti-polio immunoglobulin G) production in a sample of Egyptian children. Patients and methods This case–control study was conducted at Al Azhar University Hospital from February 2019 to February 2020. It included 150 children, aged 24 months. According to BMI centiles, they were classified into three groups: obese group and overweight group, each included 45 children, and 60 nonobese age-matched and sex-matched healthy controls. All children fulfilled both the obligatory vaccination schedule as well as additional doses. Assessment of anti-polio antibody production was done using qualitative enzyme immunoassay technique kits. Results A significantly higher anti-polio antibody production was observed in nonobese group compared with both obese and overweight children. Additional doses of polio vaccine were associated with a significant increase in antibody titer in healthy children but not in either overweight or obese children. Conclusion Obesity and overweight adversely affect the antibody production against polio vaccine.\",\"PeriodicalId\":22975,\"journal\":{\"name\":\"The Scientific Journal of Al-Azhar Medical Faculty, Girls\",\"volume\":\"39 1\",\"pages\":\"555 - 559\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Scientific Journal of Al-Azhar Medical Faculty, Girls\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/sjamf.sjamf_104_21\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Scientific Journal of Al-Azhar Medical Faculty, Girls","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/sjamf.sjamf_104_21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

摘要

肥胖是一种由多种复杂原因引起的疾病,由于能量摄入和输出之间的不平衡,导致体内多余脂肪的积累。肥胖会产生一种慢性炎症状态,对免疫系统产生不利影响,从而影响对疫苗接种的反应。目的评价超重和肥胖对埃及儿童脊髓灰质炎特异性免疫球蛋白G抗体(抗脊髓灰质炎免疫球蛋白G)产生的影响。患者和方法本病例对照研究于2019年2月至2020年2月在爱资哈尔大学医院进行。该研究包括150名24个月大的儿童。根据BMI百分位数,他们被分为三组:肥胖组和超重组,每组包括45名儿童,以及60名年龄和性别匹配的非肥胖健康对照组。所有儿童都完成了强制性疫苗接种时间表和额外剂量。使用定性酶免疫测定试剂盒对抗脊髓灰质炎抗体的生产进行评估。结果与肥胖和超重儿童相比,非肥胖组抗脊髓灰质炎抗体的产生明显较高。额外剂量的脊髓灰质炎疫苗与健康儿童抗体滴度的显著增加有关,但与超重或肥胖儿童无关。结论肥胖和超重对脊髓灰质炎疫苗抗体的产生有不利影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Estimation of poliovirus immunoglobulin G antibodies level in the healthy, overweight, and obese children
Background Obesity is a disease of multiple complex causes, leading to accumulation of excess body fat owing to imbalance between energy intake and output. Adiposity produces a state of chronic inflammation that adversely affects the immune system, which could affect the response to vaccination. Aim To evaluate the effect of overweight and obesity on the polio-specific immunoglobulin G antibodies (anti-polio immunoglobulin G) production in a sample of Egyptian children. Patients and methods This case–control study was conducted at Al Azhar University Hospital from February 2019 to February 2020. It included 150 children, aged 24 months. According to BMI centiles, they were classified into three groups: obese group and overweight group, each included 45 children, and 60 nonobese age-matched and sex-matched healthy controls. All children fulfilled both the obligatory vaccination schedule as well as additional doses. Assessment of anti-polio antibody production was done using qualitative enzyme immunoassay technique kits. Results A significantly higher anti-polio antibody production was observed in nonobese group compared with both obese and overweight children. Additional doses of polio vaccine were associated with a significant increase in antibody titer in healthy children but not in either overweight or obese children. Conclusion Obesity and overweight adversely affect the antibody production against polio vaccine.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Evaluation of nanofat injection in postburn and post-traumatic facial scars Immunological markers changes in pediatric immune Thrombocytopenic Purpura Minimally invasive strabismus surgery versus paralimbal approach for horizontal strabismus surgery Clinical applications of brain diffusion-tensor imaging and fiber tractography Choroidal and retinal nerve fiber layer thicknesses in smokers
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1