乳腺癌和前列腺癌诊断和治疗的新革命

Sherif Salah Hesen, N. Sherif
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摘要

新的肿瘤标志物以男性和女性癌基因肽蛋白及其抗肽抗体的形式被发现。在一项针对15名晚期癌症已婚患者及其丈夫和妻子的初步研究中,研究人员在女性乳腺癌患者和男性前列腺癌患者的鼠尾草和血液样本中发现了这些物质。选取年龄32 ~ 58岁乳腺癌患者10例(A组),年龄54 ~ 71岁前列腺癌患者5例(B组),年龄23 ~ 34岁正常人群4例(2男2女)作为对照组,研究血液和唾液中新型疑似癌基因肽蛋白及其特异性抗癌基因抗体的存在情况。在研究前,我们收集了三组受试者的肿瘤标志物、ct扫描、超声和乳房x光检查报告。收集数据显示,A组男性丈夫的血清和唾液样本中均存在男性癌基因肽蛋白(MOP)及其特异性抗癌基因抗体(AMOP), A组每名女性乳腺癌患者的血清样本中均存在女性癌基因肽蛋白(FOP)及其特异性抗癌基因抗体(AFOP), B组5名女性妻子均存在女性癌基因肽蛋白(FOP)及其特异性抗癌基因抗体(AFOP)。通过不同的体外和体内实验,估计正常对照和癌症患者之间的差异。我们的结论表明,OPP及其AOAbs浓度水平的升高与恶性肿瘤分期存在直接关系。通过开发治疗性和预防性癌症疫苗以及乳腺癌和前列腺癌的新生物标志物,这些有希望的结果可以为新的挑战打开大门。
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Novel Revolution in Diagnosis and Therapy of Breast and prostat e Cancer
New cancer markers have been discovered in the form of male and female oncogene peptide protein and its anti-peptide antibodies. They were found in both salvia and blood samples of females with breast cancer and males with prostate cancer, in a pilot study for fifteen married patients having cancer in advanced-stage and their Husbands and Wives. Ten females, their age ranging from 32 to 58 for breast cancer (group A), five males for prostate cancer their age ranging from 54 to 71 years (group B), and four normal persons [two male and two female], their age ranging from 23 to 34 years] (as control group), were recruited into a controlled study to investigate the presence of the new suspected oncogene peptide proteins and their specific anti-oncogene antibodies in their blood and saliva. Tumour markers, C.T scan, ultrasound, and mammogram reports were completely collected before the study for each subject in the three groups. The collection data revealed the presence of male oncogene peptide protein [MOP] in serum and saliva samples of male Husbands in group A and its specific anti-oncogene antibodies [AMOP] in the serum samples of each female affected with breast cancer in group A, and the presence of female oncogene peptide protein [FOP] in all five female Wives and its specific anti-oncogene antibodies [AFOP] in each male affected with prostate cancer in group B, and the differences between normal controls and cancer patients were estimated by different in vitro and in vivo experimental trails. Our conclusions showed that a direct relation exists between the increases in concentration levels of OPP and its AOAbs, and the stage of malignancy. These promising results can open the doors for a new challenge, by developing a therapeutic and prophylactic cancer vaccine as well as new biological markers for breast and prostate cancer.
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