老年人皮肤癌——254例患者的流行病学、临床及手术治疗分析

M. Sobjanek, I. Michajłowski, M. Malek, M. Zabłotna, A. Włodarkiewicz, R. Nowicki
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引用次数: 8

摘要

简介:在欧洲人群中,非黑色素瘤皮肤癌(NMSC)和黑色素瘤的发病率正在迅速增加。关于老年人群皮肤恶性肿瘤的报道很少。目的:分析75岁以上皮肤癌患者的流行病学、临床、组织病理学及手术治疗结果。材料和方法:研究纳入格但斯克医科大学皮肤、性病和过敏症科2002-2006年间接受手术的75岁以上患者254例。性别比率F/M为1.2。平均年龄为81.1岁。结果:75岁以上患者占分析期内因恶性肿瘤手术患者的40%。非黑色素瘤皮肤癌确诊率为92.5%,黑色素瘤确诊率为5.9%。基底细胞癌(BCC)是最常见的恶性肿瘤,诊断率为72%。与普通人群相比,鳞状细胞癌(SCC)的发病率有统计学意义(20.5% vs. 10.9%;P = 0.0002)。BCC/SCC比值为3.5。39例(16.6%)患者出现多发性NMSC。紫外线照射是皮肤恶性肿瘤最常见的危险因素(52%)。局部复发率为5.51%。结论:波兰北部75岁以上人群皮肤癌发病率呈上升趋势。老年人皮肤癌的临床和组织病理学特征不同于一般人群。手术治疗是安全有效的治疗方法。
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Original paper Skin cancer in the elderly – epidemiological, clinical and surgical treatment analysis of 254 patients
Introduction: The incidence of non-melanoma skin cancer (NMSC) and melanoma is increasing rapidly in the Euro pean population. There are only a few reports about cutaneous malignancy in the elderly population. Aim: Epidemiological, clinical, histopathological and surgical treatment result analysis of skin cancers in patients over 75 years old. Material and methods: A group of 254 patients over 75 years old operated on during 2002-2006 in the Department of Dermatology, Venerology and Allergology of the Medical University of Gdansk was included in the study. Sex ratio F/M was 1.2. The average age was 81.1 years old. Results: Patients over 75 years old comprised 40% of all operated patients because of malignancy in the analyzed period. Non-melanoma skin cancer were diagnosed in 92.5% of cases, melanoma in 5.9%. Basal cell carcinoma (BCC) was the most common malignancy, diagnosed in 72% of the patients. The incidence of squamous cell carcinoma (SCC) was statistically significantly higher compared to the general population (20.5% vs. 10.9%; p = 0.0002). BCC/SCC ratio was 3.5. In 39 patients (16.6%) multiple NMSC were observed. Exposure to UV radiation was the most com mon (52%) risk factor of cutaneous malignancy. The local recurrence rate of NMSC was 5.51%. Conclusions: The incidence of skin cancers in the northern Polish population over 75 years old is increasing. The clin ical and histopathological profile of skin cancer in the elderly differs from the general population. Surgical treatment is safe and effective management in these cases.
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