干细胞组织工程在脊髓损伤修复中的应用。

Wanting Niu, Xiang Zeng
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引用次数: 2

摘要

脊髓损伤(Spinal Cord Injury, SCI)可导致永久性的功能损害,导致单侧瘫痪、截瘫或四肢瘫痪,给患者带来巨大的社会和经济负担。内在修复机制已被证明是不足的。在当今最先进的医疗干预手段下,损伤后复杂的病理生理对功能恢复提出了巨大的挑战。因此,迫切需要制定有效的脊髓损伤治疗策略。本文综述了基于干细胞的组织工程治疗脊髓损伤的临床前和临床研究进展,重点介绍了促进脊髓损伤后功能恢复的方法,旨在为基于干细胞的组织工程设计提供一些有益的建议。
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The Application of Stem Cell Based Tissue Engineering in Spinal Cord Injury Repair.
Spinal Cord Injury (SCI) results in the permanent functional impairment, leading to monoplegia, paraplegia or tetraplegia with tremendous social and economic burden. The intrinsic repair mechanism has been proven to be insufficient. The complex pathophysiology after injury imposes enormous challenging to functional recovery, given the most advanced medical intervention nowadays. Therefore, the development of effective therapeutic strategy for spinal cord injury management is in great need. Here we review a stem cell based tissue engineering approach under preclinical or clinical development for spinal cord injury, with a focus on promoting functional recovery after SCI, aiming to provide some beneficial suggestion on stem cell based tissue engineering design.
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