{"title":"利用在线LC -生物测定、LC - NMR和LC - MS技术研究生物活性天然产物","authors":"W. Kraus","doi":"10.1081/TXR-120026909","DOIUrl":null,"url":null,"abstract":"Biologically active natural products were isolated and identified by means of online LC‐bioassay, LC‐NMR, and LC‐MS from Cussonia barteri (Araliaceae), Terminalia macroptera (Combretaceae), Jasminum subtriplinerve (Oleaceae), and Petunia hybrida (Solanaceae). From C. barteri we obtained the novel C18‐polyacetylene (+)‐9(Z),17‐octadecadiene‐12,14‐diyn‐1,11(S),16(S)‐triol (2) along with its acetate 3, and two new quinic acid esters, 1′‐O‐chlorogenoylchlorogenic acid (4) and 1′‐O‐chlorogenoylneochlorogenic acid (5). Chromatographic work up of T. macroptera extracts yielded a new hydrolyzable tannin, isoterchebulin (6), and 4,6‐O‐isoterchebuloyl‐D‐glucose (7) along with some gallic acid derivatives. From J. subtriplinerve six terpene glycosides 13–18 related to anatolioside A (12), and from P. hybrida seven highly molluscicidal sucrose esters 19–22b were isolated.","PeriodicalId":17561,"journal":{"name":"Journal of Toxicology-toxin Reviews","volume":"1 1","pages":"495 - 508"},"PeriodicalIF":0.0000,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Investigation of Biologically Active Natural Products Using Online LC‐Bioassay, LC‐NMR, and LC‐MS Techniques\",\"authors\":\"W. Kraus\",\"doi\":\"10.1081/TXR-120026909\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Biologically active natural products were isolated and identified by means of online LC‐bioassay, LC‐NMR, and LC‐MS from Cussonia barteri (Araliaceae), Terminalia macroptera (Combretaceae), Jasminum subtriplinerve (Oleaceae), and Petunia hybrida (Solanaceae). From C. barteri we obtained the novel C18‐polyacetylene (+)‐9(Z),17‐octadecadiene‐12,14‐diyn‐1,11(S),16(S)‐triol (2) along with its acetate 3, and two new quinic acid esters, 1′‐O‐chlorogenoylchlorogenic acid (4) and 1′‐O‐chlorogenoylneochlorogenic acid (5). Chromatographic work up of T. macroptera extracts yielded a new hydrolyzable tannin, isoterchebulin (6), and 4,6‐O‐isoterchebuloyl‐D‐glucose (7) along with some gallic acid derivatives. From J. subtriplinerve six terpene glycosides 13–18 related to anatolioside A (12), and from P. hybrida seven highly molluscicidal sucrose esters 19–22b were isolated.\",\"PeriodicalId\":17561,\"journal\":{\"name\":\"Journal of Toxicology-toxin Reviews\",\"volume\":\"1 1\",\"pages\":\"495 - 508\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2003-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Toxicology-toxin Reviews\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1081/TXR-120026909\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Toxicology-toxin Reviews","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1081/TXR-120026909","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 3
摘要
采用在线液相色谱-生物测定、液相色谱-核磁共振和液相色谱-质谱等方法，从五加科(Cussonia barteri)、combretacae科(Terminalia macroptera)、Jasminum subtriplinerve (Oleaceae)和矮牵牛(Petunia hybrida)中分离鉴定出具有生物活性的天然产物。从巴氏菌中，我们得到了新的C18‐聚乙炔(+)‐9(Z)、17‐十八烯二烯‐12、14‐二烯‐1、11(S)、16(S)‐三醇(2)及其乙酸3，以及两种新的奎宁酸酯，1′‐O‐绿基绿原酸(4)和1′‐O‐绿基新绿原酸(5)。对大翼虫提取物进行色谱分析，得到了一种新的可水解单宁，异terchebulin(6)和4,6‐O‐异terchebuyl - D -葡萄糖(7)以及一些没食子酸衍生物。从亚三萜苷A(12)中分离到6个萜类苷13-18，从杂交草中分离到7个高杀螺性蔗糖酯19-22b。
Investigation of Biologically Active Natural Products Using Online LC‐Bioassay, LC‐NMR, and LC‐MS Techniques
Biologically active natural products were isolated and identified by means of online LC‐bioassay, LC‐NMR, and LC‐MS from Cussonia barteri (Araliaceae), Terminalia macroptera (Combretaceae), Jasminum subtriplinerve (Oleaceae), and Petunia hybrida (Solanaceae). From C. barteri we obtained the novel C18‐polyacetylene (+)‐9(Z),17‐octadecadiene‐12,14‐diyn‐1,11(S),16(S)‐triol (2) along with its acetate 3, and two new quinic acid esters, 1′‐O‐chlorogenoylchlorogenic acid (4) and 1′‐O‐chlorogenoylneochlorogenic acid (5). Chromatographic work up of T. macroptera extracts yielded a new hydrolyzable tannin, isoterchebulin (6), and 4,6‐O‐isoterchebuloyl‐D‐glucose (7) along with some gallic acid derivatives. From J. subtriplinerve six terpene glycosides 13–18 related to anatolioside A (12), and from P. hybrida seven highly molluscicidal sucrose esters 19–22b were isolated.
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