分析取代基对喹唑啉酮席夫碱的影响及Fe (III)和Cr (III)与不同喹唑啉酮席夫碱的相互作用对抗氧化和抗炎活性的影响

Avinash Pore, G. Gaikwad, S. Hegade, Y. Jadhav, R. Mane, R. Kumbhar
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引用次数: 1

摘要

摘要希夫碱及其Fe (III)、Cr (III)配合物进行抗氧化、抗炎活性筛选和对接研究。混合配体配合物具有较强的抗氧化和抗炎作用。对混合配体复合物的对接研究表明,COX2和STAT3受体具有很强的结合亲和力。抗炎和抗氧化活性的实验结果与计算结果较为一致。图形抽象
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Analyzing the Impact of the Substituent on the Quinazolinone Schiff Base and the Interaction of the Fe (III) and Cr (III) with Different Quinazolinone Schiff Base for Antioxidant and Anti-inflammatory Activity
Abstract Schiff base and their Fe (III), Cr (III) complexes stood vetted for Antioxidant, Anti-inflammatory activities and docking study. Mixed ligand complexes had strong antioxidant and anti-inflammatory properties. Docking study of mixed ligand complexes reveals substantial binding affinity for COX2 and STAT3 receptors. The experimental and computational anti-inflammatory and antioxidant activity results are more consistent. GRAPHICAL ABSTRACT
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