{"title":"1,10-菲罗啉/β-环糊精<e:2> -聚甲基丙烯酸缩水甘油酯载药微球的制备及体外释药行为","authors":"Ya Li, W. Zhen","doi":"10.6000/1929-5995.2017.06.03.3","DOIUrl":null,"url":null,"abstract":"In this study, novel star-shaped polymers of I²-cyclodextrin (I²-CD)–poly (glycidyl methacrylate) (PGMA) were prepared by atom transfer radical polymerization (ATRP), formed from GMA and I²-CD. In addition, the structure, properties and hydrophilicity of the I²-CD-PGMA polymers thus prepared were systematically analyzed. 1,10-phenanthroline monohydrate (Phen)/I²-CD-PGMA drug-loaded microspheres were prepared by emulsion solvent evaporation. The optimum preparation conditions were determined by orthogonal tests. Analysis results indicated that the performance of star-shaped polymers of I²-CD-PGMA clearly changes, resulting in the increase of the contact angle from 17° to 72.5°, and their thermal degradation temperature was enhanced from 260 °C to 401 °C. Moreover, I²-CD-PGMA drug-loaded microspheres with a smooth, spherical surface were successfully prepared, and the drug-loading capacity and average particle size of drug-loaded microspheres were 26.67 % and 10 I¼m, respectively. Drug release tests indicated that the release behavior of I²-CD-PGMA drug-loaded microspheres conformed to Higuchi release kinetics, which exhibited a significant drug delivery capability. The release rate and utilization of I²-CD-PGMA were greater than that of I²-CD, demonstrating that I²-CD-PGMA was more suitable as a drug delivery material.","PeriodicalId":16998,"journal":{"name":"Journal of Research Updates in Polymer Science","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Preparation and In Vitro Drug Release Behavior of 1,10-Phenanthroline/β-cyclodextrin–poly (Glycidyl Methacrylate) Drug-Loaded Microspheres\",\"authors\":\"Ya Li, W. Zhen\",\"doi\":\"10.6000/1929-5995.2017.06.03.3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this study, novel star-shaped polymers of I²-cyclodextrin (I²-CD)–poly (glycidyl methacrylate) (PGMA) were prepared by atom transfer radical polymerization (ATRP), formed from GMA and I²-CD. In addition, the structure, properties and hydrophilicity of the I²-CD-PGMA polymers thus prepared were systematically analyzed. 1,10-phenanthroline monohydrate (Phen)/I²-CD-PGMA drug-loaded microspheres were prepared by emulsion solvent evaporation. The optimum preparation conditions were determined by orthogonal tests. Analysis results indicated that the performance of star-shaped polymers of I²-CD-PGMA clearly changes, resulting in the increase of the contact angle from 17° to 72.5°, and their thermal degradation temperature was enhanced from 260 °C to 401 °C. Moreover, I²-CD-PGMA drug-loaded microspheres with a smooth, spherical surface were successfully prepared, and the drug-loading capacity and average particle size of drug-loaded microspheres were 26.67 % and 10 I¼m, respectively. Drug release tests indicated that the release behavior of I²-CD-PGMA drug-loaded microspheres conformed to Higuchi release kinetics, which exhibited a significant drug delivery capability. The release rate and utilization of I²-CD-PGMA were greater than that of I²-CD, demonstrating that I²-CD-PGMA was more suitable as a drug delivery material.\",\"PeriodicalId\":16998,\"journal\":{\"name\":\"Journal of Research Updates in Polymer Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-10-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Research Updates in Polymer Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.6000/1929-5995.2017.06.03.3\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Research Updates in Polymer Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.6000/1929-5995.2017.06.03.3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Preparation and In Vitro Drug Release Behavior of 1,10-Phenanthroline/β-cyclodextrin–poly (Glycidyl Methacrylate) Drug-Loaded Microspheres
In this study, novel star-shaped polymers of I²-cyclodextrin (I²-CD)–poly (glycidyl methacrylate) (PGMA) were prepared by atom transfer radical polymerization (ATRP), formed from GMA and I²-CD. In addition, the structure, properties and hydrophilicity of the I²-CD-PGMA polymers thus prepared were systematically analyzed. 1,10-phenanthroline monohydrate (Phen)/I²-CD-PGMA drug-loaded microspheres were prepared by emulsion solvent evaporation. The optimum preparation conditions were determined by orthogonal tests. Analysis results indicated that the performance of star-shaped polymers of I²-CD-PGMA clearly changes, resulting in the increase of the contact angle from 17° to 72.5°, and their thermal degradation temperature was enhanced from 260 °C to 401 °C. Moreover, I²-CD-PGMA drug-loaded microspheres with a smooth, spherical surface were successfully prepared, and the drug-loading capacity and average particle size of drug-loaded microspheres were 26.67 % and 10 I¼m, respectively. Drug release tests indicated that the release behavior of I²-CD-PGMA drug-loaded microspheres conformed to Higuchi release kinetics, which exhibited a significant drug delivery capability. The release rate and utilization of I²-CD-PGMA were greater than that of I²-CD, demonstrating that I²-CD-PGMA was more suitable as a drug delivery material.