THP及其Ag(I)-NHC配合物药用化合物的合成方法、表征、应用领域及其抗菌效果

IF 1.3 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY Main Group Chemistry Pub Date : 2023-06-12 DOI:10.3233/mgc-220121
Murat Turkyilmaz, Murat Donmez
{"title":"THP及其Ag(I)-NHC配合物药用化合物的合成方法、表征、应用领域及其抗菌效果","authors":"Murat Turkyilmaz, Murat Donmez","doi":"10.3233/mgc-220121","DOIUrl":null,"url":null,"abstract":"Natural or synthetic substances can be used to create smart medications, which can enhance cognitive performance in healthy individuals. They are frequently used to boost memory, concentration, creativity, intelligence, and motivation in the fiercely competitive world of today.To achieve optimum results, the drug should be applied to the target site at the appropriate concentration, with as few or no adverse effects as possible due to off-target actions. Recent studies have shown that such drugs, which are often used in chemotherapy, can reduce the level of discomfort cancer patients endure. In this study, metal complexes that can carry silver nanoparticles with electrical and optical properties were formed. This article examines the potential of man-made silver N-heterocyclic complexes as smart drugs. Following the synthesis of new carbene species from the Xthantine compound, metal complexes were produced for this use. The chemical structures of these carbenes and metal complexes were investigated using a variety of methods, including melting point studies, conductivity, 1H-NMR and 13C-NMR, LC-Mass, FT-IR, TGA, and UV-vis spectrophotometry. These metal complexes differ mostly due to their solubility in water. Using the disk diffusion method, the antimicrobial and antibacterial properties of silver(I)-NHC complexes were examined against Gram-positive and Gram-negative bacteria as well as fungi. It has been observed that the antimicrobial activity of 7,9-bis(2-cyanoethyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine-9-ium silver(I)bromide compound is high. These data suggest that this compound has strong antibacterial properties.","PeriodicalId":18027,"journal":{"name":"Main Group Chemistry","volume":"17 1","pages":""},"PeriodicalIF":1.3000,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis methods, characterizations and usage areas of medicinal compounds from THP, and their Ag(I)-NHC complexes, and their antimicrobial efficiencies\",\"authors\":\"Murat Turkyilmaz, Murat Donmez\",\"doi\":\"10.3233/mgc-220121\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Natural or synthetic substances can be used to create smart medications, which can enhance cognitive performance in healthy individuals. They are frequently used to boost memory, concentration, creativity, intelligence, and motivation in the fiercely competitive world of today.To achieve optimum results, the drug should be applied to the target site at the appropriate concentration, with as few or no adverse effects as possible due to off-target actions. Recent studies have shown that such drugs, which are often used in chemotherapy, can reduce the level of discomfort cancer patients endure. In this study, metal complexes that can carry silver nanoparticles with electrical and optical properties were formed. This article examines the potential of man-made silver N-heterocyclic complexes as smart drugs. Following the synthesis of new carbene species from the Xthantine compound, metal complexes were produced for this use. The chemical structures of these carbenes and metal complexes were investigated using a variety of methods, including melting point studies, conductivity, 1H-NMR and 13C-NMR, LC-Mass, FT-IR, TGA, and UV-vis spectrophotometry. These metal complexes differ mostly due to their solubility in water. Using the disk diffusion method, the antimicrobial and antibacterial properties of silver(I)-NHC complexes were examined against Gram-positive and Gram-negative bacteria as well as fungi. It has been observed that the antimicrobial activity of 7,9-bis(2-cyanoethyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine-9-ium silver(I)bromide compound is high. These data suggest that this compound has strong antibacterial properties.\",\"PeriodicalId\":18027,\"journal\":{\"name\":\"Main Group Chemistry\",\"volume\":\"17 1\",\"pages\":\"\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2023-06-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Main Group Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.3233/mgc-220121\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Main Group Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.3233/mgc-220121","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

摘要

天然或合成物质可用于制造智能药物,从而提高健康个体的认知能力。在当今这个竞争激烈的世界里,它们经常被用来提高记忆力、注意力、创造力、智力和动力。为了达到最佳效果,药物应以适当的浓度作用于靶标部位,尽可能少或没有由于脱靶作用而产生的不良反应。最近的研究表明,这些经常用于化疗的药物可以减少癌症患者忍受的不适程度。在这项研究中,形成了可以携带具有电学和光学性质的银纳米粒子的金属配合物。本文探讨了人造银n杂环配合物作为智能药物的潜力。从Xthantine化合物中合成新的碳化合物后,金属配合物也随之产生。利用熔点、电导率、1H-NMR和13C-NMR、LC-Mass、FT-IR、TGA和UV-vis分光光度等多种方法研究了这些碳烯和金属配合物的化学结构。这些金属配合物的区别主要在于它们在水中的溶解度。采用圆盘扩散法,考察了银(I)-NHC配合物对革兰氏阳性菌和革兰氏阴性菌以及真菌的抑菌性能。已经观察到7,9-二(2-氰乙基)-1,3-二甲基-2,6-二氧基-2,3,6,7-四氢- 1h -嘌呤-9-ium银(I)溴化合物具有较高的抗菌活性。这些数据表明,该化合物具有很强的抗菌性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Synthesis methods, characterizations and usage areas of medicinal compounds from THP, and their Ag(I)-NHC complexes, and their antimicrobial efficiencies
Natural or synthetic substances can be used to create smart medications, which can enhance cognitive performance in healthy individuals. They are frequently used to boost memory, concentration, creativity, intelligence, and motivation in the fiercely competitive world of today.To achieve optimum results, the drug should be applied to the target site at the appropriate concentration, with as few or no adverse effects as possible due to off-target actions. Recent studies have shown that such drugs, which are often used in chemotherapy, can reduce the level of discomfort cancer patients endure. In this study, metal complexes that can carry silver nanoparticles with electrical and optical properties were formed. This article examines the potential of man-made silver N-heterocyclic complexes as smart drugs. Following the synthesis of new carbene species from the Xthantine compound, metal complexes were produced for this use. The chemical structures of these carbenes and metal complexes were investigated using a variety of methods, including melting point studies, conductivity, 1H-NMR and 13C-NMR, LC-Mass, FT-IR, TGA, and UV-vis spectrophotometry. These metal complexes differ mostly due to their solubility in water. Using the disk diffusion method, the antimicrobial and antibacterial properties of silver(I)-NHC complexes were examined against Gram-positive and Gram-negative bacteria as well as fungi. It has been observed that the antimicrobial activity of 7,9-bis(2-cyanoethyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purine-9-ium silver(I)bromide compound is high. These data suggest that this compound has strong antibacterial properties.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Main Group Chemistry
Main Group Chemistry 化学-化学综合
CiteScore
2.00
自引率
26.70%
发文量
65
审稿时长
>12 weeks
期刊介绍: Main Group Chemistry is intended to be a primary resource for all chemistry, engineering, biological, and materials researchers in both academia and in industry with an interest in the elements from the groups 1, 2, 12–18, lanthanides and actinides. The journal is committed to maintaining a high standard for its publications. This will be ensured by a rigorous peer-review process with most articles being reviewed by at least one editorial board member. Additionally, all manuscripts will be proofread and corrected by a dedicated copy editor located at the University of Kentucky.
期刊最新文献
Sulfone-infused covalent organic polymer derived from poly(2-aminothiophenol) and erythrosine B as an excellent tool for C–H activation Synthesis and single crystal X-ray studies of bis-(trimethylsilylmethyl) tellurium diiodide through an insertion route One-pot polycondensation and characterization of melamine-based polymer for mercury and sodium hypochlorite sensing In silico antibacterial, anticancer, antioxidant, antidiabetic activity predictions of the dual organic peroxide 2,5-dimethyl-2,5-di(tert-butyl peroxyl)hexane Syntheses characterization, and photocatalytic property of an organic-inorganic compound obtained by bromine salt and the β-Mo8O26 anion
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1