一些氧咪唑烷类和氰胍类化合物的毒理学效应及构效关系研究

Q2 Chemistry Current Chemistry Letters Pub Date : 2023-01-01 DOI:10.5267/j.ccl.2023.5.005
S. A. Abdel-Raheem, A. Drar, Bahgat R. M. Hussein, A. Moustafa
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引用次数: 1

摘要

本文报道了9种氧咪唑烷和氰胍类化合物(3a、3b、3c、3d、3e、3f、3g、4a和4b)的制备及其对豇豆蚜虫的毒理学药效试验。生物功效数据显示,化合物对这些昆虫具有一定的毒理活性,其中化合物3b的毒性最大,化合物4a的毒性最小。化合物3b对豇豆蚜成虫的LC50值为1.72 ppm,对若虫的LC50值为0.02 ppm;化合物4a对成虫的LC50值为72.51 ppm,对若虫的LC50值为18.02 ppm。本文还介绍了这些化合物的构效关系。这些结果为开发有效的害虫防治剂来管理这类昆虫提供了有价值的见解。
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Some oxoimidazolidine and cyanoguanidine compounds: Toxicological efficacy and structure-activity relationships studies
This manuscript reports the preparation and toxicological efficacy testing of nine oxoimidazolidine and cyanoguanidine compounds (3a, 3b, 3c, 3d, 3e, 3f, 3g 4a, and 4b) against cowpea aphid, Aphis craccivora Koch. Bioefficacy data revealed that the tested compounds exhibited a range of toxicological activities against these insects, with compound 3b being the most toxic and compound 4a being the least effective. The LC50 value of compound 3b was 1.72 ppm for adults and 0.02 ppm against nymphs of the cowpea aphid, while the LC50 value of compound 4a was 72.51 ppm for adults and 18.02 ppm against nymphs. The manuscript also presents the structure-activity relationships of these compounds. These results provide valuable insights into the development of effective pest control agents for the management of such insects.
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来源期刊
Current Chemistry Letters
Current Chemistry Letters Chemistry-Chemistry (all)
CiteScore
4.90
自引率
0.00%
发文量
27
审稿时长
20 weeks
期刊介绍: The "Current Chemistry Letters" is a peer-reviewed international journal which aims to publish all the current and outstanding research articles, reviews and letters in chemistry including analytical chemistry, green chemistry, inorganic chemistry, organic chemistry, physical chemistry, etc. This journal is dedicated to serve all academic and industrial researchers and scientists who are expert in all major advances in chemistry research. The journal aims to provide the most complete and reliable source of information on current developments in these fields. The emphasis will be on publishing quality articles rapidly and openly available to researchers worldwide. Please note readers are free to read, download, copy, distribute, print, search, or link to the full texts of articles published on this journal. Current Chemistry Letters is an open access journal, which provides instant access to the full text of research papers without any need for a subscription to the journal where the papers are published. Therefore, anyone has the opportunity to copy, use, redistribute, transmit/display the work publicly and to distribute derivative works, in any sort of digital form for any responsible purpose, subject to appropriate attribution of authorship. Authors who publish their articles may also maintain the copyright of their articles.
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