PM2.5、PM2.5相关空气污染物、健康危害及其对呼吸和心血管疾病的影响:系统综述和荟萃分析

A. Cheepsattayakorn, R. Cheepsattayakorn
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引用次数: 2

摘要

该研究的目的是对个人和环境中直径为2.5微米或更小的主要颗粒物浓度与心肺健康指标之间的关系进行批判性审查、探索和强有力的总结。在主流书目数据库或医学主题词中进行了全面的检索,包括Scien Direct、PubMed、Scopus和ISI Web of Science。该搜索应用于2017年至2019年初发表的文章。从每篇文章中提取所需的文章信息:直接信息包括期刊(研究文章、综述文章、会议摘要、会议摘要、通信、作者索引、编委会会议摘要、讨论)、图书章节、标题、作者、摘要、候选研究全文文件、出版年份。研究期限、采用的研究(研究)方法、研究的空气污染物类型变量;所研究的器官系统紊乱或疾病的类型,对健康的危害,对人类或动物模型的影响,新的治疗方法和经济损失的结论。经过严格的文献检索和筛选过程,共获得140篇文献(2017=45;2018 = 61;初始文献数据库(1952- 2019年初)3968篇,2019年初=34篇)。大气污染物的主要成分是PM,特别是PM2.5和PM10、O3、CO、SO2和NOx。暴露于臭氧通常与呼吸道炎症有关,而暴露于PM、CO、No2和SO2则与肺水肿、呼吸道和心血管住院以及心肺死亡率有关。任何损害内皮细胞,肺屏障完整性的关键组成部分,有助于血管渗漏和炎症。内皮细胞可能是PM暴露的目标。褪黑素对各种疾病实体的各种影响有助于假设褪黑素可能保护肺完整性免受pm2.5诱导的急性肺损伤。补肺活血(BFHX)可降低肺组织分泌性免疫球蛋白A (sIgA)和胶原纤维沉积,改善肺功能。总之,识别涉及pm诱导的心肺紊乱和疾病的各种关键信号通路可能有助于开发有效的治疗方法,包括清洁能源使用、清洁工业化、适当农业、高度土地利用多样性和适当城市化,以减少空气污染。
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PM2.5, PM2.5-related air pollutants, health hazards and impacts on respiratory and cardiovascular disorders and diseases: systematic review and meta-analysis
The objective of the study is to perform a critical review, exploration, and strong summary of the relationships between personal and ambient concentrations of mainly particulate matter with diameter of 2.5µm or less with the measures of cardiopulmonary health. A comprehensive search was carried out in mainstream bibliographic databases or Medical Subject Headings, including Scien Direct, PubMed, Scopus, and ISI Web of Science. The search was applied to the articles that were published between 2017 and early 2019. Needed article information was extracted from each article by: direct information including journal (research article, review article, meeting abstract, conference abstract, correspondence, author index, editorial board meeting abstract, discussion), book chapter, title, authors, abstract, full text documents of candidate studies, publishing year. Study period, Research (study) method used, types of air pollutants variables studied; Types of organ system disorder or disease studied The conclusions made about the health hazards, impacts on humans or animal models, novel therapeutics, and economic loss. With strict literature search and screening processes, it yielded 140 articles (2017=45; 2018=61; and early 2019=34 articles) from 3,968 articles of initial literature database (1952-early 2019). The main compositions of air pollutants are PM, particularly PM2.5 and PM10, O3, CO, SO2, and NOx. Exposure to O3 is frequently associated with respiratory tract inflammation, whereas exposure to PM, CO, No2, and SO2 is related to pulmonary edema, respiratory and cardiovascular hospitalizations, and cardiopulmonary mortality. Any compromise to endothelial cells, the key components of lung barrier integrity contributes to vascular leakage and inflammation. Endothelial cells could be the target of PM exposure. The various effects on various disease entities contribute to hypothesize that Melatonin might protect the lung integrity against PM2.5-induced acute lung injury. Bufei Huoxue (BFHX) could reduce secretory immunoglobulin A (sIgA) and collagen fibers deposition in lung, thus, improved pulmonary function. In conclusion, identification of various crucial signaling pathway involving PM-induced cardiopulmonary disorders and diseases may assist in the development of effective therapeutics, including clean energy use, clean industrialization, proper agriculture, high land use diversity, and proper urbanization for reduction of the air pollution.
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