Forensic genomics: kin privacy, driftnets and other open questions

DNA analysis is increasingly used in forensics, where it is being pushed as the holy grail of identification. But we are approaching a dramatic "phase change" as we move from genetics to genomics: when sequencing the entire genome of a person becomes sufficiently cheap as to become a routine operation, as is likely to happen in the coming decades, then each DNA examination will expose a wealth of very sensitive personal information about the examined individual, as well as her relatives. In this interdisciplinary discussion paper we highlight the complexity of DNA-related privacy issues as we move into the genomic (as opposed to genetic) era: the "driftnet" approach of comparing scene-of-crime samples against the DNA of the whole population rather than just against that of chosen suspects; the potential for errors in forensic DNA analysis and the consequences on security and privacy; the civil liberties implications of the interaction between medical and forensic applications of genomics. For example, your kin can provide valuable information in a database matching procedure against you even if you don't; and being able to read the whole of a sampled genome, rather than just 13 specific markers from it, provides information about the medical and physical characteristics of the individual. Our aim is to offer a simple but thought-provoking and technically accurate summary of the many issues involved, hoping to stimulate an informed public debate on the statutes by which DNA collection, storage and processing should be regulated.