C. Chaimbault, J. Bosc, C. Jarry, S. Daulouède, P. Vincendeau
{"title":"新型6 -氰- 2,3 -二氢- 5H -恶唑啉[3,2 - a]嘧啶- 5 -酮和2 -乙基(亚甲基氰乙酸酯)- 2 -亚胺恶唑烷的合成及初步药理评价","authors":"C. Chaimbault, J. Bosc, C. Jarry, S. Daulouède, P. Vincendeau","doi":"10.1211/146080800128735719","DOIUrl":null,"url":null,"abstract":"One-step ring-annulation of 5-substituted 2-amino-2-oxazolines with diethyl ethoxymethy-lenemalonate yielded 2-substituted 6-carboethoxy-2,3-dihydro-5H-oxazolo[3,2-a]pyrimidin-5-ones. Under the same conditions 2-substituted 6-cyano-2,3-dihydro-5H-oxazolo[3,2-a]-pyrimidin-5-ones and the corresponding 2-ethyl(methylenecyanoacetate)-2-iminooxazo-lidines were obtained from ethyl ethoxymethylenecyanoacetate. Some of these compounds were evaluated in mice for antiparasitic activity.","PeriodicalId":19946,"journal":{"name":"Pharmacy and Pharmacology Communications","volume":"168 1","pages":"101-105"},"PeriodicalIF":0.0000,"publicationDate":"2000-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Synthesis and Preliminary Pharmacological Evaluation of New 6‐cyano‐2,3‐dihydro‐5H‐oxazolo[3,2‐a]pyrimidin‐5‐ones and 2‐ethyl(methylenecyanoacetate)‐2‐iminooxazolidines\",\"authors\":\"C. Chaimbault, J. Bosc, C. Jarry, S. Daulouède, P. Vincendeau\",\"doi\":\"10.1211/146080800128735719\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"One-step ring-annulation of 5-substituted 2-amino-2-oxazolines with diethyl ethoxymethy-lenemalonate yielded 2-substituted 6-carboethoxy-2,3-dihydro-5H-oxazolo[3,2-a]pyrimidin-5-ones. Under the same conditions 2-substituted 6-cyano-2,3-dihydro-5H-oxazolo[3,2-a]-pyrimidin-5-ones and the corresponding 2-ethyl(methylenecyanoacetate)-2-iminooxazo-lidines were obtained from ethyl ethoxymethylenecyanoacetate. Some of these compounds were evaluated in mice for antiparasitic activity.\",\"PeriodicalId\":19946,\"journal\":{\"name\":\"Pharmacy and Pharmacology Communications\",\"volume\":\"168 1\",\"pages\":\"101-105\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2000-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacy and Pharmacology Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1211/146080800128735719\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacy and Pharmacology Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1211/146080800128735719","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Synthesis and Preliminary Pharmacological Evaluation of New 6‐cyano‐2,3‐dihydro‐5H‐oxazolo[3,2‐a]pyrimidin‐5‐ones and 2‐ethyl(methylenecyanoacetate)‐2‐iminooxazolidines
One-step ring-annulation of 5-substituted 2-amino-2-oxazolines with diethyl ethoxymethy-lenemalonate yielded 2-substituted 6-carboethoxy-2,3-dihydro-5H-oxazolo[3,2-a]pyrimidin-5-ones. Under the same conditions 2-substituted 6-cyano-2,3-dihydro-5H-oxazolo[3,2-a]-pyrimidin-5-ones and the corresponding 2-ethyl(methylenecyanoacetate)-2-iminooxazo-lidines were obtained from ethyl ethoxymethylenecyanoacetate. Some of these compounds were evaluated in mice for antiparasitic activity.
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