{"title":"新型噻唑类衍生物的抗菌作用研究","authors":"M. Y. Cankilic, L. Yurttaş","doi":"10.12991/MARUPJ.323584","DOIUrl":null,"url":null,"abstract":"In this work, six 2-[(1/4-methylimidazol/triazol/tetrazol- 2/3/5-yl)thio]-N-(4-substituted thiazol-2-yl) acetamide derivatives (2a-f) were synthesized. The antimicrobial activities of these substances were examined against some foodborne Gram positive and Gram negative test bacteria, Candida albicans, Candida glabrata, Candida krusei, and Candida parapsilosis yeasts, and some Aspergillus and Penicillium filamentous fungi species. The substances were shown considerable antimicrobial effect to tested pathogenic microorganisms.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"61 1","pages":"654-659"},"PeriodicalIF":0.0000,"publicationDate":"2017-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Study on the Antimicrobial Effects of Novel Thiazole Derivatives\",\"authors\":\"M. Y. Cankilic, L. Yurttaş\",\"doi\":\"10.12991/MARUPJ.323584\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this work, six 2-[(1/4-methylimidazol/triazol/tetrazol- 2/3/5-yl)thio]-N-(4-substituted thiazol-2-yl) acetamide derivatives (2a-f) were synthesized. The antimicrobial activities of these substances were examined against some foodborne Gram positive and Gram negative test bacteria, Candida albicans, Candida glabrata, Candida krusei, and Candida parapsilosis yeasts, and some Aspergillus and Penicillium filamentous fungi species. The substances were shown considerable antimicrobial effect to tested pathogenic microorganisms.\",\"PeriodicalId\":18529,\"journal\":{\"name\":\"Marmara Pharmaceutical Journal\",\"volume\":\"61 1\",\"pages\":\"654-659\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-06-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Marmara Pharmaceutical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.12991/MARUPJ.323584\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Marmara Pharmaceutical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12991/MARUPJ.323584","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
摘要
本文合成了6个2-[(1/4-甲基咪唑/三唑/四唑- 2/3/5-基)硫]- n -(4-取代噻唑-2-基)乙酰胺衍生物(2a-f)。研究了这些物质对食源性革兰氏阳性和革兰氏阴性试验菌、白色念珠菌、光秃念珠菌、克鲁氏念珠菌和副假丝酵母以及一些曲霉和青霉丝状真菌的抑菌活性。该物质对所测病原微生物有较好的抑菌作用。
Study on the Antimicrobial Effects of Novel Thiazole Derivatives
In this work, six 2-[(1/4-methylimidazol/triazol/tetrazol- 2/3/5-yl)thio]-N-(4-substituted thiazol-2-yl) acetamide derivatives (2a-f) were synthesized. The antimicrobial activities of these substances were examined against some foodborne Gram positive and Gram negative test bacteria, Candida albicans, Candida glabrata, Candida krusei, and Candida parapsilosis yeasts, and some Aspergillus and Penicillium filamentous fungi species. The substances were shown considerable antimicrobial effect to tested pathogenic microorganisms.
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