{"title":"静脉溶栓治疗在不明起病和醒后卒中中的应用:范围综述","authors":"Saima Nazish","doi":"10.56310/pjns.v17i02.184","DOIUrl":null,"url":null,"abstract":"Background : The efficacy and safety of thrombolytic therapies for the management of unknown time onset stroke (UTOS) and wake-up stroke (WUS) are in a debate. \nObjective: The objective of this scoping review is to map the existing research literature to answer the research question: What is the efficacy and safety of intravenous thrombolysis in the management of unknown time onset stroke? \nData Sources: The literature search was conducted using the search terms {(Intravenous thrombolysis)} AND {(Unknown time onset stroke)} in pub med and Intravenous thrombolysis *, Unknown time onset stroke *in Cochrane. The review was limited to articles written in the English language. Databases searched included MEDLINE, PubMed and Cochrane electronic databases complemented with a manual search. \nStudy Selection and Data Extraction: 45 articles of potential relevance were selected. Out of them 14 were containing relevant information direct to the question. The analysis was conducted by charting descriptive numerical data and by content analysis of the narrative representations \n Results: From 14 relevant papers, 2 Retrospective observational, 2 case control, 1 pilot study, and 5 recent randomized control trials were included for critical appraisal and review writing. \nConclusions: The penumbral mismatch in UTOS is a cogent method to recognize the patients for thrombolytic therapy without significant risk, but the appropriate imaging criteria to maximize the efficacy and minimize bleeding complications of thrombolytic treatment still has to be fully defined. Results from ongoing trials may be promising with the use of advanced imaging modalities in selected patients.","PeriodicalId":19818,"journal":{"name":"Pakistan Journal of Neurological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Intravenous thrombolytic therapies in the management of unknown onset and wakeup strokes: A scoping review\",\"authors\":\"Saima Nazish\",\"doi\":\"10.56310/pjns.v17i02.184\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background : The efficacy and safety of thrombolytic therapies for the management of unknown time onset stroke (UTOS) and wake-up stroke (WUS) are in a debate. \\nObjective: The objective of this scoping review is to map the existing research literature to answer the research question: What is the efficacy and safety of intravenous thrombolysis in the management of unknown time onset stroke? \\nData Sources: The literature search was conducted using the search terms {(Intravenous thrombolysis)} AND {(Unknown time onset stroke)} in pub med and Intravenous thrombolysis *, Unknown time onset stroke *in Cochrane. The review was limited to articles written in the English language. Databases searched included MEDLINE, PubMed and Cochrane electronic databases complemented with a manual search. \\nStudy Selection and Data Extraction: 45 articles of potential relevance were selected. Out of them 14 were containing relevant information direct to the question. The analysis was conducted by charting descriptive numerical data and by content analysis of the narrative representations \\n Results: From 14 relevant papers, 2 Retrospective observational, 2 case control, 1 pilot study, and 5 recent randomized control trials were included for critical appraisal and review writing. \\nConclusions: The penumbral mismatch in UTOS is a cogent method to recognize the patients for thrombolytic therapy without significant risk, but the appropriate imaging criteria to maximize the efficacy and minimize bleeding complications of thrombolytic treatment still has to be fully defined. Results from ongoing trials may be promising with the use of advanced imaging modalities in selected patients.\",\"PeriodicalId\":19818,\"journal\":{\"name\":\"Pakistan Journal of Neurological Sciences\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-12-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pakistan Journal of Neurological Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.56310/pjns.v17i02.184\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pakistan Journal of Neurological Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.56310/pjns.v17i02.184","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Intravenous thrombolytic therapies in the management of unknown onset and wakeup strokes: A scoping review
Background : The efficacy and safety of thrombolytic therapies for the management of unknown time onset stroke (UTOS) and wake-up stroke (WUS) are in a debate.
Objective: The objective of this scoping review is to map the existing research literature to answer the research question: What is the efficacy and safety of intravenous thrombolysis in the management of unknown time onset stroke?
Data Sources: The literature search was conducted using the search terms {(Intravenous thrombolysis)} AND {(Unknown time onset stroke)} in pub med and Intravenous thrombolysis *, Unknown time onset stroke *in Cochrane. The review was limited to articles written in the English language. Databases searched included MEDLINE, PubMed and Cochrane electronic databases complemented with a manual search.
Study Selection and Data Extraction: 45 articles of potential relevance were selected. Out of them 14 were containing relevant information direct to the question. The analysis was conducted by charting descriptive numerical data and by content analysis of the narrative representations
Results: From 14 relevant papers, 2 Retrospective observational, 2 case control, 1 pilot study, and 5 recent randomized control trials were included for critical appraisal and review writing.
Conclusions: The penumbral mismatch in UTOS is a cogent method to recognize the patients for thrombolytic therapy without significant risk, but the appropriate imaging criteria to maximize the efficacy and minimize bleeding complications of thrombolytic treatment still has to be fully defined. Results from ongoing trials may be promising with the use of advanced imaging modalities in selected patients.