{"title":"关注整合蛋白","authors":"Zhichao Fan, Wei Liu","doi":"10.4172/2476-1966.1000106","DOIUrl":null,"url":null,"abstract":"In mammals, there are 18 kinds of α subunit and 8 kinds of β subunit were discovered, which form 24 combinations (Table 1) [2,3]. Overall, these 24 kinds of integrins can be divided to two groups by containing α-I domain (Table 1 and Figure 1A) or not (Table 1 and Figure 1B). Integrin can regulate its ligand-binding affinity by conformational changes [1]. The adaptor proteins and signal pathways were broadly studied, as discussed in ref 1 [1].","PeriodicalId":91319,"journal":{"name":"Journal of immunobiology","volume":"114 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2016-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Keep Eyes on Integrins\",\"authors\":\"Zhichao Fan, Wei Liu\",\"doi\":\"10.4172/2476-1966.1000106\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In mammals, there are 18 kinds of α subunit and 8 kinds of β subunit were discovered, which form 24 combinations (Table 1) [2,3]. Overall, these 24 kinds of integrins can be divided to two groups by containing α-I domain (Table 1 and Figure 1A) or not (Table 1 and Figure 1B). Integrin can regulate its ligand-binding affinity by conformational changes [1]. The adaptor proteins and signal pathways were broadly studied, as discussed in ref 1 [1].\",\"PeriodicalId\":91319,\"journal\":{\"name\":\"Journal of immunobiology\",\"volume\":\"114 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of immunobiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4172/2476-1966.1000106\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of immunobiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2476-1966.1000106","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
In mammals, there are 18 kinds of α subunit and 8 kinds of β subunit were discovered, which form 24 combinations (Table 1) [2,3]. Overall, these 24 kinds of integrins can be divided to two groups by containing α-I domain (Table 1 and Figure 1A) or not (Table 1 and Figure 1B). Integrin can regulate its ligand-binding affinity by conformational changes [1]. The adaptor proteins and signal pathways were broadly studied, as discussed in ref 1 [1].